A1 Journal article (refereed)
Exercise cardiac power and the risk of heart failure in men : A population-based follow-up study (2020)


Kurl, Sudhir; Jae, Sae Young; Mäkikallio, Timo H.; Voutilainen, Ari; Hagnäs, Magnus J.; Kauhanen, Jussi; Laukkanen, Jari A. (2020). Exercise cardiac power and the risk of heart failure in men : A population-based follow-up study. Journal of Sport and Health Science, Early online. DOI: 10.1016/j.jshs.2020.02.008


JYU authors or editors


Publication details

All authors or editors: Kurl, Sudhir; Jae, Sae Young; Mäkikallio, Timo H.; Voutilainen, Ari; Hagnäs, Magnus J.; Kauhanen, Jussi; Laukkanen, Jari A.

Journal or series: Journal of Sport and Health Science

ISSN: 2095-2546

eISSN: 2213-2961

Publication year: 2020

Volume: Early online

Publisher: Elsevier

Publication country: Netherlands

Publication language: English

DOI: https://doi.org/10.1016/j.jshs.2020.02.008

Open Access: Publication published in an open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/67979


Abstract

Background
Little is known about exercise cardiac power (ECP), defined as the ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise on heart failure (HF) risk. We examined the association of ECP and the risk of HF.

Methods
This was a population-based cohort study of 2351 men from eastern Finland. The average time to follow-up was 25 years. Participants participated at baseline in an exercise stress test. A total of 313 cases of HF occurred.

Results
Men with low ECP (<9.84 mL/mmHg, lowest quartile) had a 2.37-fold (95% confidence interval (CI): 1.68 − 3.35, p < 0.0001) hazards ratio of HF as compared with men with high ECP (>13.92 mL/mmHg, highest quartile), after adjusting for age. Low ECP was associated with a 1.96-fold risk (95%CI: 1.38 − 2.78, p < 0.001) of HF after additional adjustment for conventional risk factors. After further adjustment for left ventricular hypertrophy, the results hardly changed (hazards ratio = 1.87, 95%CI: 1.31 − 2.66, p < 0.001). One SD increase in ECP (3.16 mL/mmHg) was associated with a decreased risk of HF by 28% (95%CI: 17% − 37%).

Conclusion
ECP provides a non-invasive and easily available measure from cardiopulmonary exercise test in predicting HF. However, ECP did not provide additional value over maximal oxygen uptake.


Keywords: heart; physical training; physical activeness; maximal oxygen uptake; heart failure; cardiovascular diseases; men

Free keywords: exercise cardiac power; heart failure; men


Contributing organizations


Ministry reporting: No, publication in press

Preliminary JUFO rating: 1


Last updated on 2020-18-08 at 13:42