A1 Journal article (refereed)
Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study : A Five-year Follow-up (2020)

Roine, E., Sintonen, H., Kellokumpu-Lehtinen, P.-L., Penttinen, H., Utriainen, M., Vehmanen, L., Huovinen, R., Kautiainen, H., Nikander, R., Blomqvist, C., & Saarto, T. (2020). Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study : A Five-year Follow-up. In Vivo, 34(2), 667-674. https://doi.org/10.21873/invivo.11821

JYU authors or editors

Publication details

All authors or editors: Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riika; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; et al.

Journal or series: In Vivo

ISSN: 0258-851X

eISSN: 1791-7549

Publication year: 2020

Volume: 34

Issue number: 2

Pages range: 667-674

Publisher: International Institute of Anticancer Research

Publication country: Greece

Publication language: English

DOI: https://doi.org/10.21873/invivo.11821

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/68104

Abstract

Background/Aim: As the number of breast cancer survivors is increasing, their long-term health-related quality of life (HRQoL)has become an important issue. The aim of the study is to follow up the HRQoL of breast cancer survivors (BCS) in a prospectiverandomized exercise intervention study and to compare HRQoL to that of the age-matched general female population. Patients and Methods: Following adjuvant treatment, 537 patients aged 35-68 and capable of exercise training were randomized to a 12-monthexercise trial. In 182 of those patients, HRQoL was measured by the generic 15D at baseline and followed up for five years.Furthermore, the HRQoL of all BCS answering the 15D at five-year follow-up (n=390) was compared to that of a representativesample of the general population. Results: After five years, the BCS' mean HRQoL demonstrated a statistically and clinicallysignificant impairment compared to that of the general population (difference −0.023, p<0.001). The mean HRQoL of BCS followedup from baseline until five years did not improve significantly (change=0.007, p=0.27), whereas the dimensions of usual activities(0.043, p=0.004), depression (0.038, p=0.007), distress (0.030, p=0.036), and sexual activity (0.057, p=0.009) did. Conclusion:The HRQoL of BCS was still impaired five years following treatment.

Keywords: breast cancer; cancer treatments; rehabilitation; rehabilitation patients; exercise therapy; well-being; quality of life; follow-up study

Free keywords: breast cancer; cancer; exercise; general population; health-related quality of life; physical activity; quality of life; rehabilitation; utility

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 1