A1 Journal article (refereed)
Handgrip strength is inversely associated with fatal cardiovascular and all-cause mortality events (2020)

Laukkanen, J. A., Voutilainen, A., Kurl, S., Araujo, C. G. S., Jae, S. Y., & Kunutsor, S. K. (2020). Handgrip strength is inversely associated with fatal cardiovascular and all-cause mortality events. Annals of Medicine, 52(3-4), 109-119. https://doi.org/10.1080/07853890.2020.1748220

JYU authors or editors

Publication details

All authors or editors: Laukkanen, Jari A.; Voutilainen, Ari; Kurl, Sudhir; Araujo, Claudio Gil S.; Jae, Sae Young; Kunutsor, Setor K.

Journal or series: Annals of Medicine

ISSN: 0785-3890

eISSN: 1365-2060

Publication year: 2020

Volume: 52

Issue number: 3-4

Pages range: 109-119

Publisher: Taylor & Francis

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1080/07853890.2020.1748220

Publication open access: Not open

Publication channel open access:

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/68640


Purpose: We aimed to assess the associations of handgrip strength (HS) with cardiovascular and all-cause mortality and whether adding data on HS to cardiovascular disease (CVD) risk factors is associated with improvement in CVD mortality prediction.
Design: Handgrip strength was assessed in a population-based sample of 861 participants aged 61-74 years at baseline. Relative HS was obtained by dividing the absolute value by body weight.
Results: During a median (interquartile range) follow-up of 17.3 (12.6-18.4) years, 116 fatal coronary heart diseases (CHDs), 195 fatal CVDs, and 412 all-cause mortality events occurred. On adjustment for several risk factors, the hazard ratios (95% CIs) for fatal CHD, fatal CVD, and all-cause mortality were 0.59 (0.37-0.95), 0.59 (0.41-0.86), and 0.66 (0.51-0.84) respectively comparing extreme tertiles of relative HS. Adding relative HS to a CVD mortality risk prediction model containing established risk factors did not improve discrimination or reclassification using Harrel’s C-index (C-index change: 0.0034; p = 0.65), integrated-discrimination-improvement (0.0059; p = 0.20), and net-reclassification-improvement (-1.31%; p = 0.74); however, there was a significant difference in in -2 log likelihood (p < 0.001).
Conclusion: Relative HS is inversely associated with CHD, CVD and all-cause mortality events. Adding relative HS to conventional risk factors improves CVD risk assessment using sensitive measures of discrimination.

Keywords: mortality; risk assessment; cardiovascular diseases; press force

Free keywords: handgrip strength; cardiovascular disease; mortality; risk prediction

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 2

Last updated on 2022-20-09 at 14:23