A1 Journal article (refereed)
Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland (2021)
Isiozor, N. M., Kunutsor, S. K., Voutilainen, A., Kurl, S., Kauhanen, J., & Laukkanen, J. A. (2021). Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland. European Journal of Preventive Cardiology, 28(3), 294-300. https://doi.org/10.1177/2047487320915338
JYU authors or editors
Publication details
All authors or editors: Isiozor, Nzechukwu M.; Kunutsor, Setor K.; Voutilainen, Ari; Kurl, Sudhir; Kauhanen, Jussi; Laukkanen, Jari A.
Journal or series: European Journal of Preventive Cardiology
ISSN: 2047-4873
eISSN: 2047-4881
Publication year: 2021
Volume: 28
Issue number: 3
Pages range: 294-300
Publisher: Sage Publications
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1177/2047487320915338
Publication open access: Not open
Publication channel open access:
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/74578
Abstract
Strong associations have been demonstrated between the American Heart Association’s cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) is uncertain. We examined the associations between these CVH metrics and the risks of SCD and all-cause mortality among men in Finland.
Methods and results
We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study, which consists of men between 42 and 60 years of age at baseline. CVH metrics were computed for 2577 men with CVH scores at baseline ranging from 0 to 7, categorized into CVH scores of 0–2 (poor), 3–4 (intermediate) and 5–7 (ideal). Multivariate Cox regression models were used to estimate the hazards ratios (HRs) and 95% confidence intervals (CIs) of ideal CVH metrics for SCD and all-cause mortality. During a median follow-up period of 25.8 years, 280 SCDs and 1289 all-cause mortality events were recorded. The risks of SCD and all-cause mortality decreased continuously with increasing number of CVH metrics across the range 2–7 (p value for non-linearity for all <0.05). In multivariable analyses, men with an ideal CVH score had an 85% reduced risk of SCD compared with men with a poor CVH score (HR 0.15; 95% CI 0.05–0.48; p = 0.001). For all-cause mortality, there was a 67% lower risk among men with an ideal CVH score compared with those with a poor CVH score (HR 0.33; 95% CI 0.23–0.49; p <0.001).
Conclusions
Ideal CVH metrics were strongly and linearly associated with decreased risks of SCD and all-cause mortality among middle-aged men in Finland.
Keywords: cardiovascular diseases; mortality; sudden death; risk factors; physical fitness; men
Free keywords: cardiovascular health metrics; sudden cardiac death; all-cause mortality; risk factors; men
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 1
