A1 Journal article (refereed)
Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland (2020)


Isiozor, Nzechukwu M.; Kunutsor, Setor K.; Voutilainen, Ari; Kurl, Sudhir; Kauhanen, Jussi; Laukkanen, Jari A. (2020). Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland. European Journal of Preventive Cardiology, OnlineFirst. DOI: 10.1177/2047487320915338


JYU authors or editors


Publication details

All authors or editors: Isiozor, Nzechukwu M.; Kunutsor, Setor K.; Voutilainen, Ari; Kurl, Sudhir; Kauhanen, Jussi; Laukkanen, Jari A.

Journal or series: European Journal of Preventive Cardiology

ISSN: 2047-4873

eISSN: 2047-4881

Publication year: 2020

Volume: OnlineFirst

Publisher: Sage Publications

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1177/2047487320915338

Open Access: Publication channel is not openly available


Abstract

Background
Strong associations have been demonstrated between the American Heart Association’s cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) is uncertain. We examined the associations between these CVH metrics and the risks of SCD and all-cause mortality among men in Finland.

Methods and results
We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study, which consists of men between 42 and 60 years of age at baseline. CVH metrics were computed for 2577 men with CVH scores at baseline ranging from 0 to 7, categorized into CVH scores of 0–2 (poor), 3–4 (intermediate) and 5–7 (ideal). Multivariate Cox regression models were used to estimate the hazards ratios (HRs) and 95% confidence intervals (CIs) of ideal CVH metrics for SCD and all-cause mortality. During a median follow-up period of 25.8 years, 280 SCDs and 1289 all-cause mortality events were recorded. The risks of SCD and all-cause mortality decreased continuously with increasing number of CVH metrics across the range 2–7 (p value for non-linearity for all <0.05). In multivariable analyses, men with an ideal CVH score had an 85% reduced risk of SCD compared with men with a poor CVH score (HR 0.15; 95% CI 0.05–0.48; p = 0.001). For all-cause mortality, there was a 67% lower risk among men with an ideal CVH score compared with those with a poor CVH score (HR 0.33; 95% CI 0.23–0.49; p <0.001).

Conclusions
Ideal CVH metrics were strongly and linearly associated with decreased risks of SCD and all-cause mortality among middle-aged men in Finland.


Keywords: cardiovascular diseases; mortality; sudden death; risk factors; physical fitness; men

Free keywords: cardiovascular health metrics; sudden cardiac death; all-cause mortality; risk factors; men


Contributing organizations


Ministry reporting: No, publication in press

Preliminary JUFO rating: 1


Last updated on 2020-09-07 at 23:13