A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Event-Related Potentials to Changes in Sound Intensity Demonstrate Alterations in Brain Function Related to Depression and Aging (2020)


Ruohonen, Elisa M.; Kattainen, Saara; Li, Xueqiao; Taskila, Anna-Elisa; Ye, Chaoxiong; Astikainen, Piia (2020). Event-Related Potentials to Changes in Sound Intensity Demonstrate Alterations in Brain Function Related to Depression and Aging. Frontiers in Human Neuroscience, 14, 98. DOI: 10.3389/fnhum.2020.00098


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Ruohonen, Elisa M.; Kattainen, Saara; Li, Xueqiao; Taskila, Anna-Elisa; Ye, Chaoxiong; Astikainen, Piia

Lehti tai sarja: Frontiers in Human Neuroscience

eISSN: 1662-5161

Julkaisuvuosi: 2020

Volyymi: 14

Artikkelinumero: 98

Kustantaja: Frontiers Media

Julkaisumaa: Sveitsi

Julkaisun kieli: englanti

DOI: https://doi.org/10.3389/fnhum.2020.00098

Avoin saatavuus: Open access -julkaisukanavassa ilmestynyt julkaisu

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/68472


Tiivistelmä

Measures of the brain’s automatic electrophysiological responses to sounds represent a potential tool for identifying age- and depression-related neural markers. However, these markers have rarely been studied related to aging and depression within one study. Here, we investigated auditory event-related potentials (ERPs) in the brain that may show different alterations related to aging and depression. We used an oddball condition employing changes in sound intensity to investigate: (i) sound intensity dependence; (ii) sensory gating; and (iii) change detection, all within a single paradigm. The ERPs of younger (18–40 years) and older (62–80 years) depressed female participants and age-matched non-depressed participants were measured. Intensity dependence was examined as the difference between N1 responses to repeated high- and low-intensity sounds, sensory gating as N1 responses to rare and repeated sounds, and change detection as indexed by the mismatch negativity (MMN). We found that intensity dependence was greater in older participants than younger ones, indicating effects related to aging but not to depression. For sensory gating, we found depression- and age-related alterations as increased N1 responses. No group differences were found for MMN. Although a sensory gating deficit was expected in older adults, this study is the first to demonstrate age-related overexcitability in sound intensity dependency. The results indicate that automatic brain responses to sound intensity changes are suitable for studying age- and depression-related neural markers but may not be sensitive enough to differentiate the effects of aging and depression.


YSO-asiasanat: neuropsykologia; ikääntyminen; masennus; kuulo

Vapaat asiasanat: aging; auditory-evoked potentials; depression; intensity dependence; sensory gating


Liittyvät organisaatiot

JYU-yksiköt:


OKM-raportointi: Kyllä

Raportointivuosi: 2020

Alustava JUFO-taso: 1


Viimeisin päivitys 2021-05-01 klo 10:32