A1 Journal article (refereed)
Palladium-Catalyzed [3+2] Cycloaddition of Vinylaziridine and Indane-1,3-diones : Diastereo- and Enantioselective Access to Spiro-Pyrrolidines (2020)


Vetica, Fabrizio; Bailey, Stephen J.; Kumar, Mukesh; Mahajan, Suruchi; von Essen, Carolina; Rissanen, Kari; Enders, Dieter (2020). Palladium-Catalyzed [3+2] Cycloaddition of Vinylaziridine and Indane-1,3-diones : Diastereo- and Enantioselective Access to Spiro-Pyrrolidines. Synthesis, 52 (4), 2038-2044. DOI: 10.1055/s-0040-1707472


JYU authors or editors


Publication details

All authors or editors: Vetica, Fabrizio; Bailey, Stephen J.; Kumar, Mukesh; Mahajan, Suruchi; von Essen, Carolina; Rissanen, Kari; Enders, Dieter

Journal or series: Synthesis

ISSN: 0039-7881

eISSN: 1437-210X

Publication year: 2020

Volume: 52

Issue number: 4

Pages range: 2038-2044

Publisher: Georg Thieme Verlag

Publication country: Germany

Publication language: English

DOI: http://doi.org/10.1055/s-0040-1707472

Open Access: Publication channel is not openly available


Abstract

A mild and efficient palladium-catalyzed [3+2] cycloaddition of vinylaziridine and indane-1,3-diones has been realized. The resulting spiro-pyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio­- and diastereoselectivities.


Keywords: catalysis; chemical synthesis; palladium

Free keywords: palladium catalysis; asymmetric synthesis; aziridines; sprio-pyrrolidines; indane-1,3-diones


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Ministry reporting: Yes

Preliminary JUFO rating: 1


Last updated on 2020-09-07 at 23:13