A1 Journal article (refereed)
Handgrip strength is not associated with risk of venous thromboembolism : a prospective cohort study (2020)


Kunutsor, Setor K.; Mäkikallio, Timo H.; Voutilainen, Ari; Laukkanen, Jari A. (2020). Handgrip strength is not associated with risk of venous thromboembolism : a prospective cohort study. Scandinavian Cardiovascular Journal, 54 (4), 253-257. DOI: 10.1080/14017431.2020.1751267


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Publication details

All authors or editors: Kunutsor, Setor K.; Mäkikallio, Timo H.; Voutilainen, Ari; Laukkanen, Jari A.

Journal or series: Scandinavian Cardiovascular Journal

ISSN: 1401-7431

eISSN: 1651-2006

Publication year: 2020

Volume: 54

Issue number: 4

Pages range: 253-257

Publisher: Taylor & Francis

Publication country: United Kingdom

Publication language: English

DOI: http://doi.org/10.1080/14017431.2020.1751267

Open Access: Publication channel is not openly available


Abstract

Objectives. Consistent evidence suggests an inverse and independent association between handgrip strength and arterial thrombotic disease. However, whether handgrip strength is related to future risk of venous thromboembolism (VTE) is uncertain. We sought to assess the prospective association between handgrip strength and VTE risk.
Design. Handgrip strength was assessed using a hand dynamometer in a population-based sample of 864 men and women aged 61–74 years without a history of VTE at baseline in the Kuopio Ischemic Heart Disease prospective cohort study. Handgrip strength was allometrically scaled to account for the effect of body weight (handgrip strength/body weight2/3) and to normalize the data. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for VTE.
Results. During a median (interquartile range) follow-up of 17.2 (12.1–18.3) years, 58 VTE events were recorded. The risk of VTE did not significantly decrease per 1 standard deviation increase in normalized handgrip strength in age- and sex-adjusted analysis (HR 0.89; 95% CI 0.65–1.22). The association remained similar in analyses adjusted for several established and emerging risk factors (HR 0.90; 95% CI 0.65–1.25). The corresponding adjusted HRs were 1.10 (95% CI: 0.56–2.18) and 1.15 (95% CI: 0.57–2.34), respectively, when comparing the extreme tertiles of normalized handgrip strength values.
Conclusions. Normalized handgrip strength is not associated with future VTE risk in an older Caucasian population. Large-scale studies in other populations and age-groups are warranted to generalize these findings.


Keywords: cardiovascular diseases; thrombosis; risk factors; press force; cohort study

Free keywords: handgrip strength; venous thromboembolism; cohort study


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Preliminary JUFO rating: 1


Last updated on 2020-31-07 at 08:33