A2 Review article, Literature review, Systematic review
Strategies for Exploring Functions from Dynamic Combinatorial Libraries (2020)

Jia, C., Qi, D., Zhang, Y., Rissanen, K., & Li, J. (2020). Strategies for Exploring Functions from Dynamic Combinatorial Libraries. ChemSystemsChem, 2(5), Article e2000019. https://doi.org/10.1002/syst.202000019

JYU authors or editors

Publication details

All authors or editors: Jia, Chunman; Qi, Dawei; Zhang, Yucang; Rissanen, Kari; Li, Jianwei

Journal or series: ChemSystemsChem

eISSN: 2570-4206

Publication year: 2020

Volume: 2

Issue number: 5

Article number: e2000019

Publisher: Wiley-VCH Verlag

Publication country: Germany

Publication language: English

DOI: https://doi.org/10.1002/syst.202000019

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/68693


Dynamic combinatorial chemistry (DCC) is a powerful approach for creating complex chemical systems, giving access to the studies of complexity and exploration of functionality in synthetic systems. However, compared with more advanced living systems, the man‐made chemical systems are still less functional, due to their limited complexity and insufficient kinetic control. Here we start by introducing strategies to enrich the complexity of dynamic combinatorial libraries (DCLs) for exploiting unexpected functions by increasing the species of building blocks and/or templates used. Then, we discuss how dynamic isomerization of photo‐switchable molecules help DCLs increase and alter the systemic complexity in‐situ. Multi‐phase DCLs will also be reviewed to thrive complexity and functionality across the interfaces. Finally, there will be a summary and outlook about remote kinetic control in DCLs that are realized by applying exogenous physical transduction signals of stress, light, heat and ultrasound.

Keywords: supramolecular chemistry; chemical synthesis; complexity

Free keywords: chemical complexity; dynamic combinatorial chemistry; kinetic control; noncovalent interactions; supramolecular chemistry

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 1

Last updated on 2022-20-09 at 14:41