A1 Journal article (refereed)
Anodal tDCS over the left prefrontal cortex does not cause clinically significant changes in circulating metabolites (2020)

Kortteenniemi, A. M., Ortega-Alonso, A., Javadi, A.-H., Tolmunen, T., Ali-Sisto, T., Kotilainen, T., Wikgren, J., Karhunen, L., Velagapudi, V., & Lehto, S. M. (2020). Anodal tDCS over the left prefrontal cortex does not cause clinically significant changes in circulating metabolites. Frontiers in Psychiatry, 11, Article 403. https://doi.org/10.3389/fpsyt.2020.00403

JYU authors or editors

Publication details

All authors or editors: Kortteenniemi, Aaron M.; Ortega-Alonso, Alfredo; Javadi, Amir-Homayoun; Tolmunen, Tommi; Ali-Sisto, Toni; Kotilainen, Tuukka; Wikgren, Jan; Karhunen, Leila; Velagapudi, Vidya; Lehto, Soili M.

Journal or series: Frontiers in Psychiatry

eISSN: 1664-0640

Publication year: 2020

Volume: 11

Article number: 403

Publisher: Frontiers Research Foundation

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3389/fpsyt.2020.00403

Persistent website address: https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00403

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/68892


Background: Transcranial direct current stimulation (tDCS), a putative treatment for depression, has been proposed to affect peripheral metabolism. Metabolic products from brain tissue may also cross the blood-brain-barrier, reflecting the conditions in the brain. However, there are no previous data regarding the effect of tDCS on circulating metabolites.
Objective: To determine if 5 daily sessions of tDCS modulate peripheral metabolites in healthy adult men.
Methods: This double-blind, randomized controlled trial involved 79 healthy males (aged 20–40 years) divided into two groups, one receiving tDCS (2 mA), the other being sham stimulated. The anode was placed over the left dorsolateral prefrontal cortex, and the cathode over the corresponding contralateral area. Venous blood samples were obtained before and after the first stimulation session, and after the fifth stimulation session. Serum levels of 102 metabolites were determined by mass spectrometry. The results were analysed with generalised estimating equations corrected for family-wise error rate. In addition, we performed power calculations estimating sample sizes necessary for future research.
Results: TDCS-related variation in serum metabolite levels was extremely small and statistically non-significant. Power calculations indicated that for the observed variation to be deemed significant, samples sizes of up to 11000 subjects per group would be required, depending on the metabolite of interest.
Conclusion: Our study found that 5 sessions of tDCS induced no major effects on peripheral metabolites among healthy men. These observations support the view of tDCS is a safe treatment, and do not support the previously suggested modulatory impact on peripheral metabolic processes.

Keywords: depression (mental disorders); brain; cerebral cortex; metabolism; metabolic products; brain research; neurosciences

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 1

Last updated on 2022-14-09 at 11:51