A1 Journal article (refereed)
Genomic analysis of European Drosophila melanogaster populations reveals longitudinal structure, continent-wide selection, and previously unknown DNA viruses (2020)

Kapun, M., Barrón, M. G., Staubach, F., Obbard, D. J., Wiberg, R. A. W., Vieira, J., Goubert, C., Rota-Stabelli, O., Kankare, M., Bogaerts-Márquez, M., Haudry, A., Waidele, L., Kozeretska, I., Pasyukova, E. G., Loeschcke, V., Pascual, M., Vieira, C. P., Serga, S., Montchamp-Moreau, C., . . . González, J. (2020). Genomic analysis of European Drosophila melanogaster populations reveals longitudinal structure, continent-wide selection, and previously unknown DNA viruses. Molecular Biology and Evolution, 37(9), 2661-2678. https://doi.org/10.1093/molbev/msaa120

JYU authors or editors

Publication details

All authors or editors: Kapun, Martin; Barrón, Maite G.; Staubach, Fabian; Obbard, Darren J.; Wiberg, R. Axel W.; Vieira, Jorge; Goubert, Clément; Rota-Stabelli, Omar; Kankare, Maaria; Bogaerts-Márquez, María; et al.

Journal or series: Molecular Biology and Evolution

ISSN: 0737-4038

eISSN: 1537-1719

Publication year: 2020

Volume: 37

Issue number: 9

Pages range: 2661-2678

Publisher: Oxford University Press

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1093/molbev/msaa120

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/71675

Additional information: Drosophila Real Time Evolution (Dros-RTEC) Consortium.

Abstract

Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatio-temporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide genomic analysis of genetic variation in European Drosophila melanogaster. Our analyses uncover longitudinal population structure, provide evidence for continent-wide selective sweeps, identify candidate genes for local climate adaptation, and document clines in chromosomal inversion and transposable element frequencies. We also characterise variation among populations in the composition of the fly microbiome, and identify five new DNA viruses in our samples.

Keywords: Drosophilidae; genome; genetic variation; population genetics

Contributing organizations

Related projects

Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 3