A1 Journal article (refereed)
Combined Behavioral and Mismatch Negativity Evidence for the Effects of Long-Lasting High-Definition tDCS in Disorders of Consciousness : A Pilot Study (2020)


Wang, Xiaoyu; Guo, Yongkun; Zhang, Yunge; Li, Jinju; Gao, Zhongqi; Li, Yingxin; Zhou, Tianlin; Zhang, Hui; He, Jianghong; Cong, Fengyu (2020). Combined Behavioral and Mismatch Negativity Evidence for the Effects of Long-Lasting High-Definition tDCS in Disorders of Consciousness : A Pilot Study. Frontiers in Neuroscience, 14, 381. DOI: 10.3389/fnins.2020.00381


JYU authors or editors


Publication details

All authors or editors: Wang, Xiaoyu; Guo, Yongkun; Zhang, Yunge; Li, Jinju; Gao, Zhongqi; Li, Yingxin; Zhou, Tianlin; Zhang, Hui; He, Jianghong; Cong, Fengyu

Journal or series: Frontiers in Neuroscience

ISSN: 1662-4548

eISSN: 1662-453X

Publication year: 2020

Volume: 14

Article number: 381

Publisher: Frontiers Media

Publication country: Switzerland

Publication language: English

DOI: http://doi.org/10.3389/fnins.2020.00381

Open Access: Publication published in an open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/69108


Abstract

Objective: To evaluate the effects of long-term High-definition transcranial direct current stimulation (HD-tDCS) over precuneus on the level of consciousness (LOC) and the relationship between Mismatch negativity (MMN) and the LOC over the therapy period in patients with Disorders of consciousness (DOCs).

Methods: We employed a with-in group repeated measures design with an anode HD-tDCS protocol (2 mA, 20 min, the precuneus) on 11 (2 vegetative state and nine minimally conscious state) patients with DOCs. MMN and Coma Recovery Scale-Revised (CRS-R) scores were measured at four time points: before the treatment of HD-tDCS (T0), after a single session of HD-tDCS (T1), after the treatment of 7 days (T2) and 14 days (T3). A frequency-deviant oddball paradigm with two deviation magnitudes (standard stimulus: 1000 Hz, small deviant stimuli: 1050 Hz, large deviant stimuli: 1200 Hz) was adopted to elicit MMN.

Results: Significant improvements of CRS-R score were found after 7-day (T2) and 14-day (T3) treatment compared with baseline (T0). Regarding the MMN, significant improvements of MMN amplitudes were observed after a single session of stimulation (T1), 7-day (T2) and 14-day treatment (T3) compared with baseline (T0). Additionally, there were significant negative correlations between CRS-R scores and MMN amplitudes elicited by both large and small deviant stimuli.

Conclusion: Long-term HD-tDCS over precuneus might improve signs of consciousness in patients with DOCs as measured by CRS-R total scores, and MMN could be an assistant assessment in the course of tDCS treatment.


Keywords: coma; level of consciousness; stimulation; mismatch negativity

Free keywords: high-definition transcranial direct current stimulation; disorder of consciousness; coma recovery scale-revised; mismatch negativity; event-related potentials


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2020


Last updated on 2020-09-07 at 23:11