A1 Journal article (refereed)
Laboratory-Based Gait Variability and Habitual Gait Entropy Do Not Differentiate Community-Dwelling Older Adults from Those with Subjective Memory Complaints (2020)


Rantalainen, T.; Teo, W. P.; Ridgers, N. D.; Nuzum, N. D.; Valente, L.; Macpherson, H. (2020). Laboratory-Based Gait Variability and Habitual Gait Entropy Do Not Differentiate Community-Dwelling Older Adults from Those with Subjective Memory Complaints. Gait and Posture, 80, 20-25. DOI: 10.1016/j.gaitpost.2020.05.024


JYU authors or editors


Publication details

All authors or editors: Rantalainen, T.; Teo, W. P.; Ridgers, N. D.; Nuzum, N. D.; Valente, L.; Macpherson, H.

Journal or series: Gait and Posture

ISSN: 0966-6362

eISSN: 1879-2219

Publication year: 2020

Volume: 80

Pages range: 20-25

Publisher: Elsevier

Publication country: Netherlands

Publication language: English

DOI: http://doi.org/10.1016/j.gaitpost.2020.05.024

Open Access: Publication channel is not openly available

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/69644


Abstract

Background
Age-related cognitive decline may be delayed with appropriate interventions if those at high risk can be identified prior to clinical symptoms arising. Gait variability assessment has emerged as a promising candidate prognostic indicator, however, it remains unclear how sensitive gait variability is to early changes in cognitive abilities.

Research question
Do community-dwelling adults over 65 years of age with subjective memory complaints differ from those with no subjective memory concerns in terms of laboratory-measured or free-living gait variability?

Methods
This cross-sectional study recruited 24 (age = 73.5(SD 6.4) years) community-dwelling people with subjective memory complaints and twenty seven (age = 70.9(4.3) years) individuals with no subjective memory concerns. A sample of 9 individuals with diagnosed mild dementia were also assessed (age = 86.5(7.0) years). Gait variability was assessed in a laboratory during walking at preferred pace (single-task) and while counting backward by seven (dual-task). Sixteen passes over a 4.88 m walkway in each condition were recorded and step length and duration variability was analysed. Free-living gait was assessed with a waist-worn accelerometer by identifying gait bouts of at least one min duration, and the mean multiscale sample entropy in one mins non-overlapping epochs is reported. Statistical inferences were based on analysis of variance using sex and group as the factors.

Results
No difference between those with subjective memory complaints and those without were observed in either laboratory- or free-living gait variability estimates. Both laboratory- and free-living gait variability were higher in those with mild dementia compared to the other groups.

Significance
Assuming that subjective memory complaints are on the pathway from cognitively intact to cognitively frail, the findings raise the hypothesis that subjective memory complaints occur earlier in the pathophysiology than measurable changes in laboratory or free living gait. Alternatively the gait variability assessments utilised may have been too insensitive.


Keywords: senior citizens; memory loss diseases; diagnostics; walking (motion); steps; motion analysis

Free keywords: wearable; gait; cognitive impairment; screening; activity


Contributing organizations


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Ministry reporting: Yes

Reporting Year: 2020


Last updated on 2020-18-08 at 13:31