A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16) (2020)

Thapa, C. J., Haataja, T., Pentikäinen, U., & Permi, P. (2020). 1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16). Biomolecular NMR Assignments, 14(2), 227-231. https://doi.org/10.1007/s12104-020-09951-w

JYU-tekijät tai -toimittajat

Thapa, Chandan
Haataja, Tatu
Permi, Perttu

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Thapa, Chandan J.; Haataja, Tatu; Pentikäinen, Ulla; Permi, Perttu

Lehti tai sarja: Biomolecular NMR Assignments

ISSN: 1874-2718

eISSN: 1874-270X

Julkaisuvuosi: 2020

Volyymi: 14

Lehden numero: 2

Artikkelin sivunumerot: 227-231

Kustantaja: Springer

Julkaisumaa: Alankomaat

Julkaisun kieli: englanti

DOI: https://doi.org/10.1007/s12104-020-09951-w

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/69659

Tiivistelmä

Protein Phosphatase 2A, PP2A, the principal Serine/threonine phosphatase, has major roles in broad range of signaling pathways that include regulation of cell cycle, cell proliferation and neuronal signaling. The loss of function of PP2A is linked with many human diseases, like cancer and neurodegenerative disorders. Protein phosphatase 2A (PP2A) functions as tumor suppressor and its tumor suppressor activity is inhibited by the overexpression of PP2A inhibitor proteins in most of the cancers. ARPP-19/ARPP-16 has been identified as one of the potential PP2A inhibitor proteins. Here, we report the resonance assignment of backbone 1H, 13C and 15N atoms of human ARPP-19 and ARPP-16 proteins. These chemical shift values can provide valuable information for the further study of the dynamics and interaction of ARPP-proteins to PP2A using NMR spectroscopy.

YSO-asiasanat: proteiinit; entsyymit; soluviestintä; NMR-spektroskopia

Vapaat asiasanat: assignments; cAMP-regulated phosphoprotein-19; HA-detection, intrinsically disordered protein; NMR spectroscopy

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