A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
A supramolecular system that strictly follows the binding mechanism of conformational selection (2020)
Yang, L.-P., Zhang, L., Quan, M., Ward, J. S., Ma, Y.-L., Zhou, H., Rissanen, K., & Jiang, W. (2020). A supramolecular system that strictly follows the binding mechanism of conformational selection. Nature Communications, 11, 2740. https://doi.org/10.1038/s41467-020-16534-9
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Yang, Liu-Pan; Zhang, Li; Quan, Mao; Ward, Jas S.; Ma, Yan-Long; Zhou, Hang; Rissanen, Kari; Jiang, Wei
Lehti tai sarja: Nature Communications
eISSN: 2041-1723
Julkaisuvuosi: 2020
Volyymi: 11
Artikkelin sivunumerot: 2740
Kustantaja: Nature Publishing Group
Julkaisumaa: Britannia
Julkaisun kieli: englanti
DOI: https://doi.org/10.1038/s41467-020-16534-9
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/69697
Tiivistelmä
Induced fit and conformational selection are two dominant binding mechanisms in biology. Although induced fit has been widely accepted by supramolecular chemists, conformational selection is rarely studied with synthetic systems. In the present research, we report a macrocyclic host whose binding mechanism is unambiguously assigned to conformational selection. The kinetic and thermodynamic aspects of this system are studied in great detail. It reveals that the kinetic equation commonly used for conformational selection is strictly followed here. In addition, two mathematical models are developed to determine the association constants of the same guest to the two host conformations. A “conformational selectivity factor” is defined to quantify the fidelity of conformational selection. Many details about the kinetic and thermodynamic aspects of conformational selection are revealed by this synthetic system. The conclusion and the mathematical models reported here should be helpful in understanding complex molecular recognition in both biological and synthetic systems.
YSO-asiasanat: supramolekulaarinen kemia
Vapaat asiasanat: supramolecular chemistry; conformational selection; mechanisms in biology; molecular recognition; biological systems; synthetic systems
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2020
JUFO-taso: 3
