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A supramolecular system that strictly follows the binding mechanism of conformational selection (2020)


Yang, Liu-Pan; Zhang, Li; Quan, Mao; Ward, Jas S.; Ma, Yan-Long; Zhou, Hang; Rissanen, Kari; Jiang, Wei (2020). A supramolecular system that strictly follows the binding mechanism of conformational selection. Nature Communications, 11, 2740. DOI: 10.1038/s41467-020-16534-9


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Yang, Liu-Pan; Zhang, Li; Quan, Mao; Ward, Jas S.; Ma, Yan-Long; Zhou, Hang; Rissanen, Kari; Jiang, Wei

Lehti tai sarja: Nature Communications

eISSN: 2041-1723

Julkaisuvuosi: 2020

Volyymi: 11

Artikkelin sivunumerot: 2740

Kustantaja: Nature Publishing Group

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1038/s41467-020-16534-9

Avoin saatavuus: Open access -julkaisukanavassa ilmestynyt julkaisu

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/69697


Tiivistelmä

Induced fit and conformational selection are two dominant binding mechanisms in biology. Although induced fit has been widely accepted by supramolecular chemists, conformational selection is rarely studied with synthetic systems. In the present research, we report a macrocyclic host whose binding mechanism is unambiguously assigned to conformational selection. The kinetic and thermodynamic aspects of this system are studied in great detail. It reveals that the kinetic equation commonly used for conformational selection is strictly followed here. In addition, two mathematical models are developed to determine the association constants of the same guest to the two host conformations. A “conformational selectivity factor” is defined to quantify the fidelity of conformational selection. Many details about the kinetic and thermodynamic aspects of conformational selection are revealed by this synthetic system. The conclusion and the mathematical models reported here should be helpful in understanding complex molecular recognition in both biological and synthetic systems.


YSO-asiasanat: supramolekulaarinen kemia

Vapaat asiasanat: supramolecular chemistry; conformational selection; mechanisms in biology; molecular recognition; biological systems; synthetic systems


Liittyvät organisaatiot

JYU-yksiköt:


OKM-raportointi: Kyllä

Raportointivuosi: 2020


Viimeisin päivitys 2020-18-08 klo 13:12