A2 Review article, Literature review, Systematic review
Therapeutic targets for enterovirus infections (2020)


Laajala, Mira; Reshamwala, Dhanik; Marjomäki, Varpu (2020). Therapeutic targets for enterovirus infections. Expert Opinion On Therapeutic Targets, 24 (8), 745-757. DOI: 10.1080/14728222.2020.1784141


JYU authors or editors


Publication details

All authors or editors: Laajala, Mira; Reshamwala, Dhanik; Marjomäki, Varpu

Journal or series: Expert Opinion On Therapeutic Targets

ISSN: 1472-8222

eISSN: 1744-7631

Publication year: 2020

Volume: 24

Issue number: 8

Pages range: 745-757

Publisher: Taylor & Francis

Publication country: United Kingdom

Publication language: English

DOI: http://doi.org/10.1080/14728222.2020.1784141

Open Access: Publication channel is not openly available


Abstract

Introduction
Enteroviruses are among the most common viruses causing a huge number of acute and chronic infections leading to high economic costs. Novel non-toxic antivirals that reduce the virus load in acutely infected individuals and from various surfaces are needed to efficiently combat these viruses.

Areas covered
This review summarizes the recent findings of compounds and tools targeting the enteroviruses and host cell molecules that are crucial for virus infection. In addition, the review states the modern methods to find new targets and tools that help to understand the mechanisms of action.

Expert opinion
High throughput molecular screens have revealed important aspects of virus life cycle in host cells and, concomitantly, some of the targets and compounds found serve as potential anti-virals combatting enterovirus infections. The risk of resistance development found for direct capsid binders lowers their usefulness, but combining them with compounds targeting evolutionarily conserved processes such as replication/translation makes them potentially a valid therapy for the future. Further automation and access to structural molecular tools such as cryo-EM and further development of e.g. docking and simulation of large virus particles requiring heavy computation will contribute to better understanding of molecular mechanisms of action of future antivirals.


Keywords: viruses; enteroviruses; infections; infectious diseases; medicines; pharmacotherapy; resistance (derived quantities); host cells

Free keywords: antiviral; antiviral drug resistance; capsid binder; cytotoxicity; enterovirus; high-throughput screening


Contributing organizations


Related projects

Novel probes fordiscovering anti-virals
Marjomäki, Varpu
Jane and Aatos Erkko Foundation
01/01/2017-31/12/2020


Ministry reporting: Yes


Last updated on 2020-30-09 at 09:08