A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Consequences of single-locus and tightly linked genomic architectures for evolutionary responses to environmental change (2020)
Oomen, R. A., Kuparinen, A., & Hutchings, J. A. (2020). Consequences of single-locus and tightly linked genomic architectures for evolutionary responses to environmental change. Journal of Heredity, 111(4), 319-332. https://doi.org/10.1093/jhered/esaa020
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Oomen, Rebekah A.; Kuparinen, Anna; Hutchings, Jeffrey A.
Lehti tai sarja: Journal of Heredity
ISSN: 0022-1503
eISSN: 1465-7333
Julkaisuvuosi: 2020
Volyymi: 111
Lehden numero: 4
Artikkelin sivunumerot: 319-332
Kustantaja: Oxford University Press
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1093/jhered/esaa020
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/72832
Tiivistelmä
Genetic and genomic architectures of traits under selection are key factors influencing evolutionary responses. Yet, knowledge of their impacts has been limited by a widespread assumption that most traits are controlled by unlinked polygenic architectures. Recent advances in genome sequencing and eco-evolutionary modelling are unlocking the potential for integrating genomic information into predictions of population responses to environmental change. Using eco-evolutionary simulations, we demonstrate that hypothetical single-locus control of a life history trait produces highly variable and unpredictable harvesting-induced evolution relative to the classically applied multi-locus model. Single-locus control of complex traits is thought to be uncommon, yet blocks of linked genes, such as those associated with some types of structural genomic variation, have emerged as taxonomically widespread phenomena. Inheritance of linked architectures resembles that of single loci, thus enabling single-locus-like modeling of polygenic adaptation. Yet, the number of loci, their effect sizes, and the degree of linkage among them all occur along a continuum. We review how linked architectures are often associated, directly or indirectly, with traits expected to be under selection from anthropogenic stressors and are likely to play a large role in adaptation to environmental disturbance. We suggest using single-locus models to explore evolutionary extremes and uncertainties when the trait architecture is unknown, refining parameters as genomic information becomes available, and explicitly incorporating linkage among loci when possible. By overestimating the complexity (e.g., number of independent loci) of the genomic architecture of traits under selection, we risk underestimating the complexity (e.g., nonlinearity) of their evolutionary dynamics.
YSO-asiasanat: evoluutio; geenit; perimä; ympäristönmuutokset; ilmastonmuutokset
Vapaat asiasanat: climate change; evolutionary simulation; genetic architecture; linkage disequilibrium; recombination rate; structural genomic variation
Liittyvät organisaatiot
Hankkeet, joissa julkaisu on tehty
- Resolving complex eco-evolutionary dynamics of aquatic ecosystems faced with human-induced and environmental alterations
- Kuparinen, Anna
- Euroopan komissio
- Ihmisen ja ympäristön vaikutuksia akvaattisten ekosysteemien kompleksiin eko-evolutiiviseen dynamiikkaan
- Kuparinen, Anna
- Suomen Akatemia
OKM-raportointi: Kyllä
Raportointivuosi: 2020
JUFO-taso: 1