A2 Katsausartikkeli tieteellisessä aikausilehdessä
The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance (2021)

Ahadova, A., Seppälä, T. T., Engel, C., Gallon, R., Burn, J., Holinski‐Feder, E., Steinke‐Lange, V., Möslein, G., Nielsen, M., ten Broeke, S., Laghi, L., Dominguez‐Valentin, M., Capella, G., Macrae, F., Scott, R., Hüneburg, R., Nattermann, J., Hoffmeister, M., Brenner, H., . . . Kloor, M. (2021). The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance. International Journal of Cancer, 148(4), 800-811. https://doi.org/10.1002/ijc.33224

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Ahadova, Aysel; Seppälä, Toni T.; Engel, Christoph; Gallon, Richard; Burn, John; Holinski‐Feder, Elke; Steinke‐Lange, Verena; Möslein, Gabriela; Nielsen, Maartje; ten Broeke, Sanne; et al.

Lehti tai sarja: International Journal of Cancer

ISSN: 0020-7136

eISSN: 1097-0215

Julkaisuvuosi: 2021

Ilmestymispäivä: 19.07.2020

Volyymi: 148

Lehden numero: 4

Artikkelin sivunumerot: 800-811

Kustantaja: Wiley

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1002/ijc.33224

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/74219

Tiivistelmä

Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS‐associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and of immune system in LS‐associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.

YSO-asiasanat: syöpätaudit; perinnölliset taudit; suolistosyövät; paksusuolisyöpä; Lynchin oireyhtymä; seulontatutkimus; koloskopia

Vapaat asiasanat: Lynch syndrome; colorectal cancer; colonoscopy surveillance; incident cancer risk; mismatch repair deficiency; microsatellite instability

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2021

JUFO-taso: 2