A2 Review article, Literature review, Systematic review
The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance (2021)
Ahadova, A., Seppälä, T. T., Engel, C., Gallon, R., Burn, J., Holinski‐Feder, E., Steinke‐Lange, V., Möslein, G., Nielsen, M., ten Broeke, S., Laghi, L., Dominguez‐Valentin, M., Capella, G., Macrae, F., Scott, R., Hüneburg, R., Nattermann, J., Hoffmeister, M., Brenner, H., . . . Kloor, M. (2021). The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance. International Journal of Cancer, 148(4), 800-811. https://doi.org/10.1002/ijc.33224
JYU authors or editors
Publication details
All authors or editors: Ahadova, Aysel; Seppälä, Toni T.; Engel, Christoph; Gallon, Richard; Burn, John; Holinski‐Feder, Elke; Steinke‐Lange, Verena; Möslein, Gabriela; Nielsen, Maartje; ten Broeke, Sanne; et al.
Journal or series: International Journal of Cancer
ISSN: 0020-7136
eISSN: 1097-0215
Publication year: 2021
Publication date: 19/07/2020
Volume: 148
Issue number: 4
Pages range: 800-811
Publisher: Wiley
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1002/ijc.33224
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/74219
Abstract
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS‐associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and of immune system in LS‐associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.
Keywords: cancerous diseases; hereditary diseases; bowel cancer; cancer of the large intestine; Lynch syndrome; medical screening; coloscopy
Free keywords: Lynch syndrome; colorectal cancer; colonoscopy surveillance; incident cancer risk; mismatch repair deficiency; microsatellite instability
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 2