A1 Journal article (refereed)
Prenylated Flavonoids from the Roots of Tephrosia rhodesica (2020)


Atilaw, Y., Muiva-Mutisya, L., Bogaerts, J., Duffy, S., Valkonen, A., Heydenreich, M., Avery, V. M., Rissanen, K., Erdélyi, M., & Yenesew, A. (2020). Prenylated Flavonoids from the Roots of Tephrosia rhodesica. Journal of Natural Products, 83(8), 2390-2398. https://doi.org/10.1021/acs.jnatprod.0c00245


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Publication details

All authors or editorsAtilaw, Yoseph; Muiva-Mutisya, Lois; Bogaerts, Jonathan; Duffy, Sandra; Valkonen, Arto; Heydenreich, Matthias; Avery, Vicky M.; Rissanen, Kari; Erdélyi, Máté; Yenesew, Abiy

Journal or seriesJournal of Natural Products

ISSN0163-3864

eISSN1520-6025

Publication year2020

Publication date13/08/2020

Volume83

Issue number8

Pages range2390-2398

PublisherAmerican Chemical Society (ACS)

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1021/acs.jnatprod.0c00245

Publication open accessOpenly available

Publication channel open accessPartially open access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/71417


Abstract

Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.


Keywordsnaturally occurring substancesantimicrobial compoundsflavonoidsFabaceae


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Ministry reportingYes

Reporting Year2020

JUFO rating1


Last updated on 2024-03-04 at 21:06