A1 Journal article (refereed)
Prenylated Flavonoids from the Roots of Tephrosia rhodesica (2020)


Atilaw, Yoseph; Muiva-Mutisya, Lois; Bogaerts, Jonathan; Duffy, Sandra; Valkonen, Arto; Heydenreich, Matthias; Avery, Vicky M.; Rissanen, Kari; Erdélyi, Máté; Yenesew, Abiy (2020). Prenylated Flavonoids from the Roots of Tephrosia rhodesica. Journal of Natural Products, 83 (8), 2390-2398. DOI: 10.1021/acs.jnatprod.0c00245


JYU authors or editors


Publication details

All authors or editors: Atilaw, Yoseph; Muiva-Mutisya, Lois; Bogaerts, Jonathan; Duffy, Sandra; Valkonen, Arto; Heydenreich, Matthias; Avery, Vicky M.; Rissanen, Kari; Erdélyi, Máté; Yenesew, Abiy

Journal or series: Journal of Natural Products

ISSN: 0163-3864

eISSN: 1520-6025

Publication year: 2020

Volume: 83

Issue number: 8

Pages range: 2390-2398

Publisher: American Chemical Society (ACS)

Publication country: United States

Publication language: English

DOI: http://doi.org/10.1021/acs.jnatprod.0c00245

Open Access: Open access publication published in a hybrid channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/71417


Abstract

Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.


Keywords: naturally occurring substances; antimicrobial compounds; flavonoids; Fabaceae


Contributing organizations


Related projects

Robust S...I+...S Halogen Bonded Supramolecular Assemblies (research costs)
Valkonen, Arto
Academy of Finland
01/01/2018-31/12/2020


Ministry reporting: Yes

Preliminary JUFO rating: 1


Last updated on 2020-28-10 at 08:53