A1 Journal article (refereed)
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children : the PANIC study (2020)


Lakka,Timo A.; Lintu, Niina; Väistö, Juuso; Viitasalo, Anna; Sallinen, Taisa; Haapala, Eero A.; Tompuri, Tuomo T.; Soininen, Sonja; Karjalainen, Panu; Schnurr, Theresia M.; Mikkonen, Santtu et al. (2020). A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children : the PANIC study. Diabetologia, 63 (11), 2270-2281. DOI: 10.1007/s00125-020-05250-0


JYU authors or editors


Publication details

All authors or editors: Lakka,Timo A.; Lintu, Niina; Väistö, Juuso; Viitasalo, Anna; Sallinen, Taisa; Haapala, Eero A.; Tompuri, Tuomo T.; Soininen, Sonja; Karjalainen, Panu; Schnurr, Theresia M.; et al.

Journal or series: Diabetologia

ISSN: 0012-186X

eISSN: 1432-0428

Publication year: 2020

Volume: 63

Issue number: 11

Pages range: 2270-2281

Publisher: Springer

Publication country: Germany

Publication language: English

DOI: http://doi.org/10.1007/s00125-020-05250-0

Open Access: Open access publication published in a hybrid channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/71510


Abstract

Aims/hypothesis
We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly normal-weight children.

Methods
We carried out a 2 year non-randomised controlled trial in a population sample of 504 children aged 6–9 years at baseline. The children were allocated to a combined physical activity and dietary intervention group (306 children at baseline, 261 children at 2-year follow-up) or a control group (198 children, 177 children) without blinding. We measured fasting insulin and fasting glucose, calculated HOMA-IR, assessed physical activity and sedentary time by combined heart rate and body movement monitoring, assessed dietary factors by a 4 day food record, used the Finnish Children Healthy Eating Index (FCHEI) as a measure of overall diet quality, and measured body fat percentage (BF%) and lean body mass by dual-energy x-ray absorptiometry. The intervention effects on insulin, glucose and HOMA-IR were analysed using the intention-to-treat principle and linear mixed-effects models after adjustment for sex, age at baseline, and pubertal status at baseline and 2 year follow-up. The measures of physical activity, sedentary time, diet and body composition at baseline and 2 year follow-up were entered one-by-one as covariates into the models to study whether changes in these variables might partly explain the observed intervention effects.

Results
Compared with the control group, fasting insulin increased 4.65 pmol/l less (absolute change +8.96 vs +13.61 pmol/l) and HOMA-IR increased 0.18 units less (+0.31 vs +0.49 units) over 2 years in the combined physical activity and dietary intervention group. The intervention effects on fasting insulin (regression coefficient β for intervention effect −0.33 [95% CI −0.62, −0.04], p = 0.026) and HOMA-IR (β for intervention effect −0.084 [95% CI −0.156, −0.012], p = 0.023) were statistically significant after adjustment for sex, age at baseline, and pubertal status at baseline and 2 year follow-up. The intervention had no effect on fasting glucose, BF% or lean body mass. Changes in total physical activity energy expenditure, light physical activity, moderate-to-vigorous physical activity, total sedentary time, the reported consumption of high-fat (≥60%) vegetable oil-based spreads, and FCHEI, but not a change in BF% or lean body mass, partly explained the intervention effects on fasting insulin and HOMA-IR.

Conclusions/interpretation
The combined physical activity and dietary intervention attenuated the increase in insulin resistance over 2 years in a general population of predominantly normal-weight children. This beneficial effect was partly mediated by changes in physical activity, sedentary time and diet but not changes in body composition.


Keywords: children (age groups); body composition; diets; glucose; insulin; physical activeness; intervention study

Free keywords: body fat; children; diet; glucose; HOMA-IR; insulin; intervention; lean body mass; physical activity; sedentary time


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Ministry reporting: Yes

Preliminary JUFO rating: 2


Last updated on 2020-01-10 at 10:01