A1 Journal article (refereed)
Secoiridoids and Iridoids from Morinda asteroscepa (2020)

Zandi, L., Makungu, M., Munissi, J. J. E., Duffy, S., Puttreddy, R., von der Heiden, D., Rissanen, K., Avery, V. M., Nyandoro, S. S., & Erdélyi, M. (2020). Secoiridoids and Iridoids from Morinda asteroscepa. Journal of Natural Products, 83(9), 2641-2646. https://doi.org/10.1021/acs.jnatprod.0c00447

JYU authors or editors

Publication details

All authors or editors: Zandi, Linda; Makungu, Marco; Munissi, Joan J. E.; Duffy, Sandra; Puttreddy, Rakesh; von der Heiden, Daniel; Rissanen, Kari; Avery, Vicky M.; Nyandoro, Stephen S.; Erdélyi, Máté

Journal or series: Journal of Natural Products

ISSN: 0163-3864

eISSN: 1520-6025

Publication year: 2020

Volume: 83

Issue number: 9

Pages range: 2641-2646

Publisher: American Chemical Society (ACS)

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1021/acs.jnatprod.0c00447

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/71578

Abstract

The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).

Keywords: naturally occurring substances; organic compounds; antimicrobial compounds; Rubiaceae

Free keywords: chemical structure; organic compounds; alkyls; nuclear magnetic resonance spectroscopy

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Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 1