A1 Journal article (refereed)
Secoiridoids and Iridoids from Morinda asteroscepa (2020)


Zandi, L., Makungu, M., Munissi, J. J. E., Duffy, S., Puttreddy, R., von der Heiden, D., Rissanen, K., Avery, V. M., Nyandoro, S. S., & Erdélyi, M. (2020). Secoiridoids and Iridoids from Morinda asteroscepa. Journal of Natural Products, 83(9), 2641-2646. https://doi.org/10.1021/acs.jnatprod.0c00447


JYU authors or editors


Publication details

All authors or editorsZandi, Linda; Makungu, Marco; Munissi, Joan J. E.; Duffy, Sandra; Puttreddy, Rakesh; von der Heiden, Daniel; Rissanen, Kari; Avery, Vicky M.; Nyandoro, Stephen S.; Erdélyi, Máté

Journal or seriesJournal of Natural Products

ISSN0163-3864

eISSN1520-6025

Publication year2020

Publication date27/08/2020

Volume83

Issue number9

Pages range2641-2646

PublisherAmerican Chemical Society (ACS)

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1021/acs.jnatprod.0c00447

Publication open accessOpenly available

Publication channel open accessPartially open access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/71578


Abstract

The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).


Keywordsnaturally occurring substancesorganic compoundsantimicrobial compoundsRubiaceae

Free keywordschemical structure; organic compounds; alkyls; nuclear magnetic resonance spectroscopy


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Ministry reportingYes

Reporting Year2020

JUFO rating1


Last updated on 2024-03-04 at 21:06