A1 Journal article (refereed)
Secoiridoids and Iridoids from Morinda asteroscepa (2020)


Zandi, Linda; Makungu, Marco; Munissi, Joan J. E.; Duffy, Sandra; Puttreddy, Rakesh; von der Heiden, Daniel; Rissanen, Kari; Avery, Vicky M.; Nyandoro, Stephen S.; Erdélyi, Máté (2020). Secoiridoids and Iridoids from Morinda asteroscepa. Journal of Natural Products, 83 (9), 2641-2646. DOI: 10.1021/acs.jnatprod.0c00447


JYU authors or editors


Publication details

All authors or editors: Zandi, Linda; Makungu, Marco; Munissi, Joan J. E.; Duffy, Sandra; Puttreddy, Rakesh; von der Heiden, Daniel; Rissanen, Kari; Avery, Vicky M.; Nyandoro, Stephen S.; Erdélyi, Máté

Journal or series: Journal of Natural Products

ISSN: 0163-3864

eISSN: 1520-6025

Publication year: 2020

Volume: 83

Issue number: 9

Pages range: 2641-2646

Publisher: American Chemical Society (ACS)

Publication country: United States

Publication language: English

DOI: http://doi.org/10.1021/acs.jnatprod.0c00447

Open Access: Open access publication published in a hybrid channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/71578


Abstract

The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).


Keywords: naturally occurring substances; organic compounds; antimicrobial compounds; Rubiaceae

Free keywords: chemical structure; organic compounds; alkyls; nuclear magnetic resonance spectroscopy


Contributing organizations


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Ministry reporting: Yes

Preliminary JUFO rating: 1


Last updated on 2020-28-10 at 08:54