A1 Journal article (refereed)
Secoiridoids and Iridoids from Morinda asteroscepa (2020)
Zandi, Linda; Makungu, Marco; Munissi, Joan J. E.; Duffy, Sandra; Puttreddy, Rakesh; von der Heiden, Daniel; Rissanen, Kari; Avery, Vicky M.; Nyandoro, Stephen S.; Erdélyi, Máté (2020). Secoiridoids and Iridoids from Morinda asteroscepa. Journal of Natural Products, 83 (9), 2641-2646. DOI: 10.1021/acs.jnatprod.0c00447
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Publication details
All authors or editors: Zandi, Linda; Makungu, Marco; Munissi, Joan J. E.; Duffy, Sandra; Puttreddy, Rakesh; von der Heiden, Daniel; Rissanen, Kari; Avery, Vicky M.; Nyandoro, Stephen S.; Erdélyi, Máté
Journal or series: Journal of Natural Products
ISSN: 0163-3864
eISSN: 1520-6025
Publication year: 2020
Volume: 83
Issue number: 9
Pages range: 2641-2646
Publisher: American Chemical Society (ACS)
Publication country: United States
Publication language: English
DOI: http://doi.org/10.1021/acs.jnatprod.0c00447
Open Access: Open access publication published in a hybrid channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/71578
Abstract
The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).
Keywords: naturally occurring substances; organic compounds; antimicrobial compounds; Rubiaceae
Free keywords: chemical structure; organic compounds; alkyls; nuclear magnetic resonance spectroscopy
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Preliminary JUFO rating: 1
