A2 Review article, Literature review, Systematic review
Biological basis of bone strength : Anatomy, physiology and measurement (2020)


Hart, Nicolas H.; Newton, Robert U.; Tan, Jocelyn; Rantalainen, Timo; Chivers, Paola; Siafarikas, Aris; Nimphius, Sophia (2020). Biological basis of bone strength : Anatomy, physiology and measurement. Journal of Musculoskeletal and Neuronal Interactions, 20 (3), 347-371. http://www.ismni.org/jmni/pdf/81/jmni_20_347.pdf


JYU authors or editors


Publication details

All authors or editors: Hart, Nicolas H.; Newton, Robert U.; Tan, Jocelyn; Rantalainen, Timo; Chivers, Paola; Siafarikas, Aris; Nimphius, Sophia

Journal or series: Journal of Musculoskeletal and Neuronal Interactions

ISSN: 1108-7161

Publication year: 2020

Volume: 20

Issue number: 3

Pages range: 347-371

Publisher: International Society of Musculoskeletal and Neuronal Interactions

Publication country: Greece

Publication language: English

Persistent website address: http://www.ismni.org/jmni/pdf/81/jmni_20_347.pdf

Open Access: Publication published in an open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/71714


Abstract

Understanding how bones are innately designed, robustly developed and delicately maintained through intricate anatomical features and physiological processes across the lifespan is vital to inform our assessment of normal bone health, and essential to aid our interpretation of adverse clinical outcomes affecting bone through primary or secondary causes. Accordingly this review serves to introduce new researchers and clinicians engaging with bone and mineral metabolism, and provide a contemporary update for established researchers or clinicians. Specifically, we describe the mechanical and non-mechanical functions of the skeleton; its multidimensional and hierarchical anatomy (macroscopic, microscopic, organic, inorganic, woven and lamellar features); its cellular and hormonal physiology (deterministic and homeostatic processes that govern and regulate bone); and processes of mechanotransduction, modelling, remodelling and degradation that underpin bone adaptation or maladaptation. In addition, we also explore commonly used methods for measuring bone metabolic activity or material features (imaging or biochemical markers) together with their limitations.


Keywords: bone; bony tissues; bone density; imaging; modelling (creation related to information)

Free keywords: cortical; remodelling; trabecular


Contributing organizations


Ministry reporting: Yes

Preliminary JUFO rating: 1


Last updated on 2020-10-09 at 13:28