A2 Katsausartikkeli tieteellisessä aikausilehdessä
Biological basis of bone strength : Anatomy, physiology and measurement (2020)

Hart, N. H., Newton, R. U., Tan, J., Rantalainen, T., Chivers, P., Siafarikas, A., & Nimphius, S. (2020). Biological basis of bone strength : Anatomy, physiology and measurement. Journal of Musculoskeletal and Neuronal Interactions, 20(3), 347-371. http://www.ismni.org/jmni/pdf/81/jmni_20_347.pdf

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Hart, Nicolas H.; Newton, Robert U.; Tan, Jocelyn; Rantalainen, Timo; Chivers, Paola; Siafarikas, Aris; Nimphius, Sophia

Lehti tai sarja: Journal of Musculoskeletal and Neuronal Interactions

ISSN: 1108-7161

Julkaisuvuosi: 2020

Volyymi: 20

Lehden numero: 3

Artikkelin sivunumerot: 347-371

Kustantaja: International Society of Musculoskeletal and Neuronal Interactions

Julkaisumaa: Kreikka

Julkaisun kieli: englanti

Pysyvä verkko-osoite: http://www.ismni.org/jmni/pdf/81/jmni_20_347.pdf

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/71714

Tiivistelmä

Understanding how bones are innately designed, robustly developed and delicately maintained through intricate anatomical features and physiological processes across the lifespan is vital to inform our assessment of normal bone health, and essential to aid our interpretation of adverse clinical outcomes affecting bone through primary or secondary causes. Accordingly this review serves to introduce new researchers and clinicians engaging with bone and mineral metabolism, and provide a contemporary update for established researchers or clinicians. Specifically, we describe the mechanical and non-mechanical functions of the skeleton; its multidimensional and hierarchical anatomy (macroscopic, microscopic, organic, inorganic, woven and lamellar features); its cellular and hormonal physiology (deterministic and homeostatic processes that govern and regulate bone); and processes of mechanotransduction, modelling, remodelling and degradation that underpin bone adaptation or maladaptation. In addition, we also explore commonly used methods for measuring bone metabolic activity or material features (imaging or biochemical markers) together with their limitations.

YSO-asiasanat: luu; luukudokset; luuntiheys; kuvantaminen; mallintaminen

Vapaat asiasanat: cortical; remodelling; trabecular

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2020

JUFO-taso: 1