A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD (2020)
Lehti, M., Valkeinen, H., Sipilä, S., Perhonen, M., Rottensteiner, M., Pullinen, T., Pietiläinen, R., Nyman, K., Vehkaoja, A., Kainulainen, H., & Kujala, U. M. (2020). Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD. American Journal of Translational Research, 12(8), 4582-4593. http://www.ajtr.org/files/ajtr0107339.pdf
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Lehti, Maarit; Valkeinen, Heli; Sipilä, Sarianna; Perhonen, Merja; Rottensteiner, Mirva; Pullinen, Teemu; Pietiläinen, Rauno; Nyman, Kai; Vehkaoja, Antti; Kainulainen, Heikki; et al.
Lehti tai sarja: American Journal of Translational Research
eISSN: 1943-8141
Julkaisuvuosi: 2020
Volyymi: 12
Lehden numero: 8
Artikkelin sivunumerot: 4582-4593
Kustantaja: e-Century Publishing Corporation
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
Pysyvä verkko-osoite: http://www.ajtr.org/files/ajtr0107339.pdf
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/72088
Julkaisu on rinnakkaistallennettu: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476147/
Tiivistelmä
This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO2peak), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and suitability of the program were assessed by wireless electrocardiogram (ECG) monitoring and exercise diaries. VO2peak (6.9%; P < 0.05) and exercise time (11.2%; P < 0.05) improved significantly after 12 weeks of training in the MIAST group compared to the control group. Muscle strength (19.9%; P < 0.05) and CSA (2.2%; P < 0.05) increased, and serum lipids and blood glucose tended to decrease after the training. The successful training program (increase in maximal oxygen uptake) increased the gene expression of oxygen metabolism and decreased the gene expression of inflammation pathways in lymphomonocytes. The MIAST program, including interval-type aerobic and strength training, was safe, did not cause any adverse effects, and led to significant improvements in physical fitness in patients with stable CAD.
YSO-asiasanat: sepelvaltimotauti; potilaat; fyysinen kunto; hapenotto; maksimaalinen hapenotto; lihasvoima; liikuntahoito; kestävyysharjoittelu; voimaharjoittelu
Vapaat asiasanat: coronary heart disease; physical fitness; oxygen consumption; endurance training; resistance training
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2020
JUFO-taso: 1
