A1 Journal article (refereed)
Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD (2020)

Lehti, M., Valkeinen, H., Sipilä, S., Perhonen, M., Rottensteiner, M., Pullinen, T., Pietiläinen, R., Nyman, K., Vehkaoja, A., Kainulainen, H., & Kujala, U. M. (2020). Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD. American Journal of Translational Research, 12(8), 4582-4593. http://www.ajtr.org/files/ajtr0107339.pdf

JYU authors or editors

Publication details

All authors or editors: Lehti, Maarit; Valkeinen, Heli; Sipilä, Sarianna; Perhonen, Merja; Rottensteiner, Mirva; Pullinen, Teemu; Pietiläinen, Rauno; Nyman, Kai; Vehkaoja, Antti; Kainulainen, Heikki; et al.

Journal or series: American Journal of Translational Research

eISSN: 1943-8141

Publication year: 2020

Volume: 12

Issue number: 8

Pages range: 4582-4593

Publisher: e-Century Publishing Corporation

Publication country: United States

Publication language: English

Persistent website address: http://www.ajtr.org/files/ajtr0107339.pdf

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/72088

Publication is parallel published: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476147/


This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO2peak), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and suitability of the program were assessed by wireless electrocardiogram (ECG) monitoring and exercise diaries. VO2peak (6.9%; P < 0.05) and exercise time (11.2%; P < 0.05) improved significantly after 12 weeks of training in the MIAST group compared to the control group. Muscle strength (19.9%; P < 0.05) and CSA (2.2%; P < 0.05) increased, and serum lipids and blood glucose tended to decrease after the training. The successful training program (increase in maximal oxygen uptake) increased the gene expression of oxygen metabolism and decreased the gene expression of inflammation pathways in lymphomonocytes. The MIAST program, including interval-type aerobic and strength training, was safe, did not cause any adverse effects, and led to significant improvements in physical fitness in patients with stable CAD.

Keywords: coronary disease; patients; physical fitness; oxygen uptake; maximal oxygen uptake; muscle strength; exercise therapy; endurance training; strength training

Free keywords: coronary heart disease; physical fitness; oxygen consumption; endurance training; resistance training

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 1

Last updated on 2022-20-09 at 13:55