A1 Journal article (refereed)
Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer (2020)
Junttila, A., Helminen, O., Väyrynen, J. P., Ahtiainen, M., Kenessey, I., Jalkanen, S., Mecklin, J.-P., Kellokumpu, I., Kuopio, T., Böhm, J., & Mrena, J. (2020). Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer. British Journal of Cancer, 123(11), 1625-1632. https://doi.org/10.1038/s41416-020-01053-7
JYU authors or editors
Publication details
All authors or editors: Junttila, Anna; Helminen, Olli; Väyrynen, Juha P.; Ahtiainen, Maarit; Kenessey, Istvan; Jalkanen, Sirpa; Mecklin, Jukka-Pekka; Kellokumpu, Ilmo; Kuopio, Teijo; Böhm, Jan; et al.
Journal or series: British Journal of Cancer
ISSN: 0007-0920
eISSN: 1532-1827
Publication year: 2020
Volume: 123
Issue number: 11
Pages range: 1625-1632
Publisher: Nature Publishing Group
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1038/s41416-020-01053-7
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/77920
Abstract
Methods: After exclusion of Epstein-Barr virus positive (n = 4) and microsatellite instable (n = 6) tumours, the study included 122 patients with GC undergoing D2 gastrectomy. CD3+ and CD8+ based ICS, PD-L1, PD-1 and Clever-1 expressions were evaluated. Differences in survival were examined using Cox regression adjusted for confounders. The primary outcome was 5-year survival.
Results: The 5-year overall survival rate was 43.4%. High ICS was associated with improved overall survival (adjusted HR 0.48 (95% CI 0.26-0.87)) compared to low ICS. In the high ICS group, patients with PD-L1 expression (5-year survival 69.2 vs. 53.1%, p = 0.317), high PD-1 (5-year survival 70.6 vs. 55.3% p = 0.312) and high Clever-1 (5-year survival 72.0% vs. 45.5% (p = 0.070) had poor prognosis.
Conclusions: High ICS was associated with improved survival. In the high ICS group, patients with high PD-L1, PD-1 and Clever-1 had poor prognosis highlighting the importance of immune escape and immune tolerance in GC.
Keywords: cancerous diseases; gastric cancer; forecasts; immune response; phenotype
Contributing organizations
Ministry reporting: Yes
VIRTA submission year: 2020
JUFO rating: 2
