A2 Review article, Literature review, Systematic review
Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases? (2020)

Freitag, N., Doma, K., Neunhaeuserer, D., Cheng, S., Bloch, W., & Schumann, M. (2020). Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?. Journal of Personalized Medicine, 10(3), Article 135. https://doi.org/10.3390/jpm10030135

JYU authors or editors

Publication details

All authors or editors: Freitag, Nils; Doma, Kenji; Neunhaeuserer, Daniel; Cheng, Sulin; Bloch, Wilhelm; Schumann, Moritz

Journal or series: Journal of Personalized Medicine

eISSN: 2075-4426

Publication year: 2020

Volume: 10

Issue number: 3

Article number: 135

Publisher: MDPI

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3390/jpm10030135

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/72106

Abstract

Aim: This systematic review aimed to explore the literature to identify in which types of chronic diseases exercise with supplemental oxygen has previously been utilized and whether this type of personalized therapy leads to superior effects in physical fitness and well-being. Methods: Databases (PubMed/MEDLINE, CINHAL, EMBASE, Web of knowledge and Cochrane Library) were searched in accordance with PRISMA. Eligibility criteria included adult patients diagnosed with any type of chronic diseases engaging in supervised exercise training with supplemental oxygen compared to normoxia. A random-effects model was used to pool effect sizes by standardized mean differences (SMD). Results: Out of the identified 4038 studies, 12 articles were eligible. Eleven studies were conducted in chronic obstructive pulmonary disease (COPD), while one study included coronary artery disease (CAD) patients. No statistical differences were observed for markers of physical fitness and patient-reported outcomes on well-being between the two training conditions (SMD −0.10; 95% CI −0.27, 0.08; p = 0.26). Conclusions: We found that chronic exercise with supplemental oxygen has mainly been utilized for COPD patients. Moreover, no superior long-term adaptations on physical fitness, functional capacity or patient-reported well-being were found, questioning the role of this method as a personalized medicine approach.

Keywords: chronic diseases; exercise therapy; exercise (people); oxygen therapy; systematic reviews

Free keywords: exercise medicine; clinical exercise science; individualized exercise prescription; FiO2; hyperoxia; oxygen therapy

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 1