A1 Journal article (refereed)
Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease : an fNIRS study protocol for randomized controlled trial in Dalian, China (2020)


Pu, L., Qureshi, N. K., Ly, J., Zhang, B., Cong, F., Tang, W. C., & Liang, Z. (2020). Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease : an fNIRS study protocol for randomized controlled trial in Dalian, China. Trials, 21, Article 864. https://doi.org/10.1186/s13063-020-04770-9


JYU authors or editors


Publication details

All authors or editors: Pu, Lanlan; Qureshi, Nauman Khalid; Ly, Joanne; Zhang, Bingwei; Cong, Fengyu; Tang, William C.; Liang, Zhanhua

Journal or series: Trials

eISSN: 1745-6215

Publication year: 2020

Volume: 21

Article number: 864

Publisher: BioMed Central

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1186/s13063-020-04770-9

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/72254


Abstract

Background
Music therapy improves neuronal activity and connectivity of healthy persons and patients with clinical symptoms of neurological diseases like Parkinson’s disease, Alzheimer’s disease, and major depression. Despite the plethora of publications that have reported the positive effects of music interventions, little is known about how music improves neuronal activity and connectivity in afflicted patients.

Methods
For patients suffering from Parkinson’s disease (PD), we propose a daily 25-min music-based synchronous finger tapping (SFT) intervention for 8 weeks. Eligible participants with PD are split into two groups: an intervention group and a control arm. In addition, a third cohort of healthy controls will be recruited. Assessment of finger tapping performances, the Unified Parkinson’s Disease Rating Scale (UPDRS), an n-back test, the Montreal Cognitive Assessment (MoCA), as well as oxygenated hemoglobin (HbO2), deoxygenated hemoglobin (HbR), and total hemoglobin activation collected by functional near-infrared spectroscopy (fNIRS) are measured at baseline, week 4 (during), week 8 (post), and week 12 (retention) of the study. Data collected from the two PD groups are compared to baseline performances from healthy controls.

Discussion
This exploratory prospective trial study investigates the cortical neuronal activity and therapeutic effects associated with an auditory external cue used to induce automatic and implicit synchronous finger tapping in patients diagnosed with PD. The extent to which the intervention is effective may be dependent on the severity of the disease. The study’s findings are used to inform larger clinical studies for optimization and further exploration of the therapeutic effects of movement-based music therapy on neural activity in neurological diseases.

Trial registration
ClinicalTrials.gov NCT04212897. Registered on December 30, 2019. The participant recruitment and study protocol have received ethical approval from the First Affiliated Hospital of Dalian Medical University. The hospital Protocol Record number is PJ-KY-2019-123. The protocol was named “fNIRS Studies of Music Intervention of Parkinson’s Disease.” The current protocol is version 1.1, revised on September 1, 2020.


Keywords: music therapy; Parkinson's disease; neurodegenerative diseases; treatment methods; neurons; cerebral cortex; music

Free keywords: music therapy; Parkinson’s disease; fNIRS; randomized controlled trials; explicit and implicit timing; motor-control; synchronous finger tapping


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 1


Last updated on 2021-17-09 at 16:43