A1 Journal article (refereed)
Joint effect of blood pressure and C-reactive protein and the risk of sudden cardiac death : a prospective cohort study (2021)
Kurl, S., Jae, S. Y., Voutilainen, A., Mäkikallio, T., & Laukkanen, J. A. (2021). Joint effect of blood pressure and C-reactive protein and the risk of sudden cardiac death : a prospective cohort study. International Journal of Cardiology, 326, 184-188. https://doi.org/10.1016/j.ijcard.2020.10.071
JYU authors or editors
Publication details
All authors or editors: Kurl, Sudhir; Jae, Sae Y.; Voutilainen, Ari; Mäkikallio, Timo; Laukkanen, Jari A.
Journal or series: International Journal of Cardiology
ISSN: 0167-5273
eISSN: 1874-1754
Publication year: 2021
Volume: 326
Pages range: 184-188
Publisher: Elsevier
Publication country: Ireland
Publication language: English
DOI: https://doi.org/10.1016/j.ijcard.2020.10.071
Publication open access: Not open
Publication channel open access:
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/74222
Abstract
Both blood pressure and C-reactive protein (CRP) are each independently related to mortality risk. However, the combined effect of systolic blood pressure (SBP) and CRP on sudden cardiac death (SCD) risk has not been studied.
Patients and methods
We studied the joint impact of SBP and CRP and the risk of SCD in the Kuopio Ischemic Heart Disease prospective cohort study of 1953 men aged 42–61 years with no history of ischemic heart disease. Baseline investigations were conducted between March 1984 and December 1989. SBP and CRP were measured. SBP was divided based on median values to low and high (median cutoffs 132 mmHg) and CRP as low and high (median cut-off 1.30 mg/L). Hazard ratios (HRs) with confidence intervals (CIs) were calculated after multivariate adjustment.
Results
Subjects were followed-up for 23.2 years, and 137 SCDs occurred. In this study, elevated SBP (>132 mmHg) combined with elevated (CRP >1.30 mg/L) were associated with SCD risk. Adjustment for age, examination year, alcohol consumption, BMI, energy expenditure during exercise, total cholesterol, HDL-cholesterol, type 2 diabetes, smoking, antihypertension medication and aspirin use, the risk of SCD remained statistically significant (HR, 2,73, 95% CI, 1.62–4.60, p < .001). Further adjustment for socio-economic status, years of education and history of cardiovascular disease in a family the results were only slightly changed (HR, 2.65, 95% CI, 1.57–4.49, p < .001).
Conclusions
In our male cohort study, the joint effect of high SBP together with increased CRP levels is a risk predictor of SCD compared with low SBP and CRP.
Keywords: cardiovascular diseases; myocardial infarction; risk factors; biomarkers; c-reactive protein; blood pressure; hypertension; men
Free keywords: C-reactive protein; men; sudden cardiac death; systolic blood pressure
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 1
