A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Impaired glucose regulation, depressive symptoms, and health-related quality of life (2020)


Selenius, J. S., Wasenius, N. S., Kautiainen, H., Salonen, M., von Bonsdorff, M., & Eriksson, J. G. (2020). Impaired glucose regulation, depressive symptoms, and health-related quality of life. BMJ Open Diabetes Research and Care, 8, Article e001568. https://doi.org/10.1136/bmjdrc-2020-001568


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Selenius, Jannica S.; Wasenius, Niko S.; Kautiainen, Hannu; Salonen, Minna; von Bonsdorff, Mikaela; Eriksson, Johan G.

Lehti tai sarja: BMJ Open Diabetes Research and Care

eISSN: 2052-4897

Julkaisuvuosi: 2020

Volyymi: 8

Artikkelinumero: e001568

Kustantaja: BMJ Publishing Group Ltd

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1136/bmjdrc-2020-001568

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/72561

Julkaisu on rinnakkaistallennettu: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574885/


Tiivistelmä

Introduction: This study aims to investigate whether the associations between impaired glucose regulation and health-related quality of life are modified by severity or type of depressive symptoms.

Research design and methods: For this cross-sectional study, we included 1939 individuals (mean age 61.5 years) from the Helsinki Birth Cohort Study. Between 2001 and 2004, a standard 2-hour 75 g oral glucose tolerance test was applied to define normoglycemia, pre-diabetes, and newly diagnosed diabetes. Information on previously diagnosed diabetes was collected from national registers and questionnaires. Pre-diabetes was defined as having either impaired fasting glucose or impaired glucose tolerance. The Mental and Physical Component Scores of health-related quality of life were assessed with Short Form-36. Beck's Depression Inventory was employed to investigate the severity of depressive symptoms and to define minimal (depression score <10), non-melancholic, and melancholic types of depression. We analyzed data with general linear models adjusted for sex, age, lifestyle factors, comorbidities, and body mass index.

Results: Glucose regulation subgroups, especially previously known diabetes, were associated with lower Physical Component Score (p=0.001) and higher depression score (p=0.015), but not with the Mental Component Score (p=0.189). Non-melancholic depression was associated with lower Physical and Mental Component Scores compared with those with depression score <10 and melancholic depression (p<0.001), independently of glucose regulation status (p for glucose regulation status by depression type interaction >0.54).

Conclusions: Non-melancholic type of depression and previously known diabetes are independently associated with lower health-related quality of life. This should be appraised in long-term treatment of diabetes and when treating non-melancholic depressive symptoms to maintain a higher health-related quality of life.


YSO-asiasanat: keski-ikäiset; ikääntyneet; insuliiniresistenssi; aikuistyypin diabetes; fyysinen hyvinvointi; henkinen hyvinvointi; masennus; elämänlaatu

Vapaat asiasanat: depression; diabetes mellitus; insulin resistance; quality of life; type 2


Liittyvät organisaatiot


OKM-raportointi: Kyllä

Raportointivuosi: 2020

JUFO-taso: 1


Viimeisin päivitys 2021-17-09 klo 16:04