A1 Journal article (refereed)
Gating Patterns to Proprioceptive Stimulation in Various Cortical Areas : An MEG Study in Children and Adults using Spatial ICA (2021)

Vallinoja, J., Jaatela, J., Nurmi, T., & Piitulainen, H. (2021). Gating Patterns to Proprioceptive Stimulation in Various Cortical Areas : An MEG Study in Children and Adults using Spatial ICA. Cerebral Cortex, 31(3), 1523-1537. https://doi.org/10.1093/cercor/bhaa306

JYU authors or editors

Nurmi, Timo
Piitulainen, Harri

Publication details

All authors or editors: Vallinoja, Jaakko; Jaatela, Julia; Nurmi, Timo; Piitulainen, Harri

Journal or series: Cerebral Cortex

ISSN: 1047-3211

eISSN: 1460-2199

Publication year: 2021

Volume: 31

Issue number: 3

Pages range: 1523-1537

Publisher: Oxford University Press

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1093/cercor/bhaa306

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/72595

Abstract

Proprioceptive paired-stimulus paradigm was used for 30 children (10-17 years) and 21 adult (25-45 years) volunteers in magnetoencephalography (MEG). Their right index finger was moved twice with 500-ms interval every 4 ± 25 s (repeated 100 times) using a pneumatic-movement actuator. Spatial-independent component analysis (ICA) was applied to identify stimulus-related components from MEG cortical responses. Clustering was used to identify spatiotemporally consistent components across subjects. We found a consistent primary response in the primary somatosensory (SI) cortex with similar gating ratios of 0.72 and 0.69 for the children and adults, respectively. Secondary responses with similar transient gating behavior were centered bilaterally in proximity of the lateral sulcus. Delayed and prolonged responses with strong gating were found in the frontal and parietal cortices possibly corresponding to larger processing network of somatosensory afference. No significant correlation between age and gating ratio was found. We confirmed that cortical gating to proprioceptive stimuli is comparable to other somatosensory and auditory domains, and between children and adults. Gating occurred broadly beyond SI cortex. Spatial ICA revealed several consistent response patterns in various cortical regions which would have been challenging to detect with more commonly applied equivalent current dipole or distributed source estimates.

Keywords: kinaesthesia; stimuli (role related to effect); MEG; signal analysis

Free keywords: independent component analysis; magnetoencephalography; paired stimulus; proprioception; somatosensory

Fields of science: