A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Intranasal oxytocin decreases fear generalization in males, but does not modulate discrimination threshold (2021)


Dou, H., Zou, L., Becker, B., & Lei, Y. (2021). Intranasal oxytocin decreases fear generalization in males, but does not modulate discrimination threshold. Psychopharmacology, 238(3), 677-689. https://doi.org/10.1007/s00213-020-05720-8


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Dou, Haoran; Zou, Liye; Becker, Benjamin; Lei, Yi

Lehti tai sarja: Psychopharmacology

ISSN: 0033-3158

eISSN: 1432-2072

Julkaisuvuosi: 2021

Volyymi: 238

Lehden numero: 3

Artikkelin sivunumerot: 677-689

Kustantaja: Springer

Julkaisumaa: Saksa

Julkaisun kieli: englanti

DOI: https://doi.org/10.1007/s00213-020-05720-8

Julkaisun avoin saatavuus: Ei avoin

Julkaisukanavan avoin saatavuus: 

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/80490


Tiivistelmä

Background: A previously acquired fear response often spreads to perceptually or conceptually close stimuli or contexts. This process, known as fear generalization, facilitates the avoidance of danger, and dysregulations in this process play an important role in anxiety disorders. Oxytocin (OT) has been shown to modulate fear learning, yet effects on fear generalization remain unknown.

Methods: We employed a randomized, placebo-controlled, double-blind, between-subject design during which healthy male participants received either intranasal OT or placebo (PLC) following fear acquisition and before fear generalization with concomitant acquisition of skin conductance responses (SCRs). Twenty-four to 72 h before the fear learning and immediately after the fear generalization task, participants additionally complete a discrimination threshold task.

Results: Relative to PLC, OT significantly reduced perceived risk and SCRs towards the CS+ and GS1 (the generalization stimulus that is most similar to CS+) during fear generalization, whereas the discrimination threshold was not affected.

Conclusions: Together, the results suggest that OT can attenuate fear generalization in the absence of effects on discrimination threshold. This study provides the first evidence for effects of OT on fear generalization in humans and suggests that OT may have therapeutic potential in anxiety disorders characterized by dysregulated fear generalization.


YSO-asiasanat: pelko; ehdollistuminen; ahdistuneisuushäiriöt; oksitosiini

Vapaat asiasanat: discrimination threshold; fear generalization; oxytocin; skin conductance responses (SCRs).


Liittyvät organisaatiot

JYU-yksiköt:


OKM-raportointi: Kyllä

Raportointivuosi: 2021

JUFO-taso: 1


Viimeisin päivitys 2024-22-04 klo 18:09