A1 Journal article (refereed)
Intranasal oxytocin decreases fear generalization in males, but does not modulate discrimination threshold (2021)
Dou, H., Zou, L., Becker, B., & Lei, Y. (2021). Intranasal oxytocin decreases fear generalization in males, but does not modulate discrimination threshold. Psychopharmacology, 238(3), 677-689. https://doi.org/10.1007/s00213-020-05720-8
JYU authors or editors
Publication details
All authors or editors: Dou, Haoran; Zou, Liye; Becker, Benjamin; Lei, Yi
Journal or series: Psychopharmacology
ISSN: 0033-3158
eISSN: 1432-2072
Publication year: 2021
Volume: 238
Issue number: 3
Pages range: 677-689
Publisher: Springer
Publication country: Germany
Publication language: English
DOI: https://doi.org/10.1007/s00213-020-05720-8
Publication open access: Not open
Publication channel open access:
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/80490
Abstract
Methods: We employed a randomized, placebo-controlled, double-blind, between-subject design during which healthy male participants received either intranasal OT or placebo (PLC) following fear acquisition and before fear generalization with concomitant acquisition of skin conductance responses (SCRs). Twenty-four to 72 h before the fear learning and immediately after the fear generalization task, participants additionally complete a discrimination threshold task.
Results: Relative to PLC, OT significantly reduced perceived risk and SCRs towards the CS+ and GS1 (the generalization stimulus that is most similar to CS+) during fear generalization, whereas the discrimination threshold was not affected.
Conclusions: Together, the results suggest that OT can attenuate fear generalization in the absence of effects on discrimination threshold. This study provides the first evidence for effects of OT on fear generalization in humans and suggests that OT may have therapeutic potential in anxiety disorders characterized by dysregulated fear generalization.
Keywords: fear (emotions); conditioning (passive); anxiety disorders; oxytocin
Free keywords: discrimination threshold; fear generalization; oxytocin; skin conductance responses (SCRs).
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 1