A1 Journal article (refereed)
Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives (2021)


Kiss, L., Nonn, M., Kara, D., Ouchakour, L., Forró, E., & Haukka, M. (2021). Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives. Synthesis: Stuttgart, 53(06), 1163-1173. https://doi.org/10.1055/s-0040-1706637


JYU authors or editors


Publication details

All authors or editors: Kiss, Loránd; Nonn, Melinda; Kara, Dominika; Ouchakour, Lamiaa; Forró, Enikő; Haukka, Matti

Journal or series: Synthesis: Stuttgart

ISSN: 0039-7881

eISSN: 1437-210X

Publication year: 2021

Volume: 53

Issue number: 06

Pages range: 1163-1173

Publisher: Georg Thieme Verlag KG

Publication country: Germany

Publication language: English

DOI: https://doi.org/10.1055/s-0040-1706637

Publication open access: Not open

Publication channel open access:


Abstract

Structural diversity-oriented synthesis of some azaheterocyclic β-amino acid derivatives has been accomplished by selective functionalization of readily available cyclodienes. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of unsaturated cyclic β-amino acids derived from cycloalkadiene, followed by ring closing with double reductive amination, which furnished some conformationally restricted β-amino acid derivatives with a piperidine or azepane core.


Keywords: amino acids; derivatives (chemistry); fluorine; chemical synthesis; isomerism

Free keywords: azaheterocyles; structural diversity; amino acids; stereocontrol; selectivity


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2021

Preliminary JUFO rating: 1


Last updated on 2021-07-07 at 17:54