A1 Journal article (refereed)
Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives (2021)
Kiss, L., Nonn, M., Kara, D., Ouchakour, L., Forró, E., & Haukka, M. (2021). Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives. Synthesis: Stuttgart, 53(06), 1163-1173. https://doi.org/10.1055/s-0040-1706637
JYU authors or editors
Publication details
All authors or editors: Kiss, Loránd; Nonn, Melinda; Kara, Dominika; Ouchakour, Lamiaa; Forró, Enikő; Haukka, Matti
Journal or series: Synthesis: Stuttgart
ISSN: 0039-7881
eISSN: 1437-210X
Publication year: 2021
Publication date: 14/12/2020
Volume: 53
Issue number: 06
Pages range: 1163-1173
Publisher: Georg Thieme Verlag KG
Publication country: Germany
Publication language: English
DOI: https://doi.org/10.1055/s-0040-1706637
Publication open access: Not open
Publication channel open access:
Abstract
Structural diversity-oriented synthesis of some azaheterocyclic β-amino acid derivatives has been accomplished by selective functionalization of readily available cyclodienes. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of unsaturated cyclic β-amino acids derived from cycloalkadiene, followed by ring closing with double reductive amination, which furnished some conformationally restricted β-amino acid derivatives with a piperidine or azepane core.
Keywords: amino acids; derivatives (chemistry); fluorine; chemical synthesis; isomerism
Free keywords: azaheterocyles; structural diversity; amino acids; stereocontrol; selectivity
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 1