A1 Journal article (refereed)
Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives (2021)


Kiss, Loránd; Nonn, Melinda; Kara, Dominika; Ouchakour, Lamiaa; Forró, Enikő; Haukka, Matti (2021). Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives. Synthesis: Stuttgart, 53 (06), 1163-1173. DOI: 10.1055/s-0040-1706637


JYU authors or editors


Publication details

All authors or editors: Kiss, Loránd; Nonn, Melinda; Kara, Dominika; Ouchakour, Lamiaa; Forró, Enikő; Haukka, Matti

Journal or series: Synthesis: Stuttgart

ISSN: 0039-7881

eISSN: 1437-210X

Publication year: 2021

Volume: 53

Issue number: 06

Pages range: 1163-1173

Publisher: Georg Thieme Verlag KG

Publication country: Germany

Publication language: English

DOI: https://doi.org/10.1055/s-0040-1706637

Open Access: Publication channel is not openly available


Abstract

Structural diversity-oriented synthesis of some azaheterocyclic β-amino acid derivatives has been accomplished by selective functionalization of readily available cyclodienes. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of unsaturated cyclic β-amino acids derived from cycloalkadiene, followed by ring closing with double reductive amination, which furnished some conformationally restricted β-amino acid derivatives with a piperidine or azepane core.


Keywords: amino acids; derivatives (chemistry); fluorine; chemical synthesis; isomerism

Free keywords: azaheterocyles; structural diversity; amino acids; stereocontrol; selectivity


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Ministry reporting: Yes

Preliminary JUFO rating: 1


Last updated on 2021-01-03 at 13:13