A1 Journal article (refereed)
Binding motif of ebselen in solution : chalcogen and hydrogen bonds team up (2020)
Daolio, A., Scilabra, P., Di Pietro, M. E., Resnati, C., Rissanen, K., & Resnati, G. (2020). Binding motif of ebselen in solution : chalcogen and hydrogen bonds team up. New Journal of Chemistry, 44(47), 20697-20703. https://doi.org/10.1039/d0nj04647g
JYU authors or editors
Publication details
All authors or editors: Daolio, Andrea; Scilabra, Patrick; Di Pietro, Maria Enrica; Resnati, Chiara; Rissanen, Kari; Resnati, Giuseppe
Journal or series: New Journal of Chemistry
ISSN: 1144-0546
eISSN: 1369-9261
Publication year: 2020
Publication date: 21/12/2020
Volume: 44
Issue number: 47
Pages range: 20697-20703
Publisher: Royal Society of Chemistry
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1039/d0nj04647g
Publication open access: Not open
Publication channel open access:
Abstract
Ebselen (2-phenyl-1,2-benzoselenazol-3(2H)one), a glutathione peroxidase mimic, is active against several RNA viruses, among others the retrovirus responsible for the COVID-19 pandemic. In this paper Se-77 and H-1 NMR studies of ebselen are reported and they identify the chalcogen bond (ChB) and hydrogen bond (HB) that are central in the landscape of interactions formed by the compound in solution. The selenium atom and the hydrogen atom at the C7 carbon act as ChB and HB donors and the O and N atoms of neutral molecules function as acceptors. The ChB and HB give rise to a bifurcated supramolecular synthon, which fastens the interaction acceptor opposite to the N-Se covalent bond of the selenazole ring. It is known that the biologically important reaction of ebselen with cysteine thiol groups is favoured when selenium acts as a chalcogen bond donor.
Keywords: organic compounds; amino acids; selenium; chemical bonds; antimicrobial compounds; viruses
Free keywords: amino acids; atoms; Selenium; Selenium compounds; viruses
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2020
JUFO rating: 1