A1 Journal article (refereed)
Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages (2021)

Penttinen, R., Given, C., & Jalasvuori, M. (2021). Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages. Microorganisms, 9(2), Article 280. https://doi.org/10.3390/microorganisms9020280

JYU authors or editors

Publication details

All authors or editorsPenttinen, Reetta; Given, Cindy; Jalasvuori, Matti

Journal or seriesMicroorganisms


Publication year2021

Publication date29/01/2021


Issue number2

Article number280

PublisherMDPI AG

Publication countrySwitzerland

Publication languageEnglish


Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/73977


Antibiotic resistance genes of important Gram-negative bacterial pathogens are residing in mobile genetic elements such as conjugative plasmids. These elements rapidly disperse between cells when antibiotics are present and hence our continuous use of antimicrobials selects for elements that often harbor multiple resistance genes. Plasmid-dependent (or male-specific or, in some cases, pilus-dependent) bacteriophages are bacterial viruses that infect specifically bacteria that carry certain plasmids. The introduction of these specialized phages into a plasmid-abundant bacterial community has many beneficial effects from an anthropocentric viewpoint: the majority of the plasmids are lost while the remaining plasmids acquire mutations that make them untransferable between pathogens. Recently, bacteriophage-based therapies have become a more acceptable choice to treat multi-resistant bacterial infections. Accordingly, there is a possibility to utilize these specialized phages, which are not dependent on any particular pathogenic species or strain but rather on the resistance-providing elements, in order to improve or enlengthen the lifespan of conventional antibiotic approaches. Here, we take a snapshot of the current knowledge of plasmid-dependent bacteriophages.

Keywordsantibiotic resistanceplasmidsbacteriophages

Free keywordsantibiotic resistance; conjugative plasmids; plasmid-dependent; male-specific; pilus-binding; bacteriophages

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Ministry reportingYes

Reporting Year2021

JUFO rating1

Last updated on 2024-22-04 at 13:45