A2 Review article, Literature review, Systematic review
Atomically Precise Gold Nanoclusters : Towards an Optimal Biocompatible System from a Theoretical–Experimental Strategy (2021)


Matus, M. F., & Häkkinen, H. (2021). Atomically Precise Gold Nanoclusters : Towards an Optimal Biocompatible System from a Theoretical–Experimental Strategy. Small, 17(27), Article 2005499. https://doi.org/10.1002/smll.202005499


JYU authors or editors


Publication details

All authors or editorsMatus, María Francisca; Häkkinen, Hannu

Journal or seriesSmall

ISSN1613-6810

eISSN1613-6829

Publication year2021

Publication date02/02/2021

Volume17

Issue number27

Article number2005499

PublisherWiley-VCH Verlag

Publication countryGermany

Publication languageEnglish

DOIhttps://doi.org/10.1002/smll.202005499

Publication open accessNot open

Publication channel open access

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/93662

Additional informationConcept.


Abstract

Potential biomedical applications of gold nanoparticles have increasingly been reported with great promise for diagnosis and therapy of several diseases. However, for such a versatile nanomaterial, the advantages and potential health risks need to be addressed carefully, as the available information about their toxicity is limited and inconsistent. Atomically precise gold nanoclusters (AuNCs) have emerged to overcome this challenge due to their unique features, such as superior stability, excellent biocompatibility, and efficient renal clearance. Remarkably, the elucidation of their structural and physicochemical properties provided by theory–experiment investigations offers exciting opportunities for site‐specific biofunctionalization of the nanoparticle surface, which remains a significant concern for most of the materials in the biomedical field. This concept highlights the advantages conferred by atomically precise AuNCs for biomedical applications and the powerful strategy combining computational and experimental studies towards finding an optimal biocompatible AuNCs‐based nanosystem.


Keywordsnanoparticlesnanomaterialsgoldbiological activitynanomedicine

Free keywordsatomistic simulations; biocompatibility; biomedical applications; gold nanoclusters; nanomedicine


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Ministry reportingYes

Reporting Year2021

JUFO rating2


Last updated on 2024-10-03 at 20:06