A2 Review article, Literature review, Systematic review
Atomically Precise Gold Nanoclusters : Towards an Optimal Biocompatible System from a Theoretical–Experimental Strategy (2021)

Matus, M. F., & Häkkinen, H. (2021). Atomically Precise Gold Nanoclusters : Towards an Optimal Biocompatible System from a Theoretical–Experimental Strategy. Small, 17(27), Article 2005499. https://doi.org/10.1002/smll.202005499

JYU authors or editors

Publication details

All authors or editors: Matus, María Francisca; Häkkinen, Hannu

Journal or series: Small

ISSN: 1613-6810

eISSN: 1613-6829

Publication year: 2021

Publication date: 02/02/2021

Volume: 17

Issue number: 27

Article number: 2005499

Publisher: Wiley-VCH Verlag

Publication country: Germany

Publication language: English

DOI: https://doi.org/10.1002/smll.202005499

Publication open access: Not open

Publication channel open access:

Additional information: Concept.


Potential biomedical applications of gold nanoparticles have increasingly been reported with great promise for diagnosis and therapy of several diseases. However, for such a versatile nanomaterial, the advantages and potential health risks need to be addressed carefully, as the available information about their toxicity is limited and inconsistent. Atomically precise gold nanoclusters (AuNCs) have emerged to overcome this challenge due to their unique features, such as superior stability, excellent biocompatibility, and efficient renal clearance. Remarkably, the elucidation of their structural and physicochemical properties provided by theory–experiment investigations offers exciting opportunities for site‐specific biofunctionalization of the nanoparticle surface, which remains a significant concern for most of the materials in the biomedical field. This concept highlights the advantages conferred by atomically precise AuNCs for biomedical applications and the powerful strategy combining computational and experimental studies towards finding an optimal biocompatible AuNCs‐based nanosystem.

Keywords: nanoparticles; nanomaterials; gold; biological activity; nanomedicine

Free keywords: atomistic simulations; biocompatibility; biomedical applications; gold nanoclusters; nanomedicine

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Ministry reporting: Yes

Reporting Year: 2021

JUFO rating: 2

Last updated on 2022-19-08 at 19:16