A2 Review article, Literature review, Systematic review
Atomically Precise Gold Nanoclusters : Towards an Optimal Biocompatible System from a Theoretical–Experimental Strategy (2021)
Matus, M. F., & Häkkinen, H. (2021). Atomically Precise Gold Nanoclusters : Towards an Optimal Biocompatible System from a Theoretical–Experimental Strategy. Small, 17(27), Article 2005499. https://doi.org/10.1002/smll.202005499
JYU authors or editors
Publication details
All authors or editors: Matus, María Francisca; Häkkinen, Hannu
Journal or series: Small
ISSN: 1613-6810
eISSN: 1613-6829
Publication year: 2021
Publication date: 02/02/2021
Volume: 17
Issue number: 27
Article number: 2005499
Publisher: Wiley-VCH Verlag
Publication country: Germany
Publication language: English
DOI: https://doi.org/10.1002/smll.202005499
Publication open access: Not open
Publication channel open access:
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/93662
Additional information: Concept.
Abstract
Potential biomedical applications of gold nanoparticles have increasingly been reported with great promise for diagnosis and therapy of several diseases. However, for such a versatile nanomaterial, the advantages and potential health risks need to be addressed carefully, as the available information about their toxicity is limited and inconsistent. Atomically precise gold nanoclusters (AuNCs) have emerged to overcome this challenge due to their unique features, such as superior stability, excellent biocompatibility, and efficient renal clearance. Remarkably, the elucidation of their structural and physicochemical properties provided by theory–experiment investigations offers exciting opportunities for site‐specific biofunctionalization of the nanoparticle surface, which remains a significant concern for most of the materials in the biomedical field. This concept highlights the advantages conferred by atomically precise AuNCs for biomedical applications and the powerful strategy combining computational and experimental studies towards finding an optimal biocompatible AuNCs‐based nanosystem.
Keywords: nanoparticles; nanomaterials; gold; biological activity; nanomedicine
Free keywords: atomistic simulations; biocompatibility; biomedical applications; gold nanoclusters; nanomedicine
Contributing organizations
Related projects
- Metalli-molekyyli-rajapintojen nanorakenteet (NaMeMoInt)
- Häkkinen, Hannu
- Research Council of Finland
- Metalli-molekyyli-rajapintojen nanorakenteet (NaMeMolnt)
- Häkkinen, Hannu
- Research Council of Finland
- NANOSTRUCTURED METAL – MOLECULE INTERFACES
- Häkkinen, Hannu
- Research Council of Finland
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 2