A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Neural generators of the frequency-following response elicited to stimuli of low and high frequency : a magnetoencephalographic (MEG) study (2021)


Gorina-Careta, N., Kurkela, J. L., Hämäläinen, J., Astikainen, P., & Escera, C. (2021). Neural generators of the frequency-following response elicited to stimuli of low and high frequency : a magnetoencephalographic (MEG) study. NeuroImage, 231. https://doi.org/10.1016/j.neuroimage.2021.117866


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Gorina-Careta, Natàlia; Kurkela, Jari L.O.; Hämäläinen, Jarmo; Astikainen, Piia; Escera, Carles

Lehti tai sarja: NeuroImage

ISSN: 1053-8119

eISSN: 1095-9572

Julkaisuvuosi: 2021

Volyymi: 231

Artikkelinumero: 117866

Kustantaja: Elsevier

Julkaisumaa: Alankomaat

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.neuroimage.2021.117866

Avoin saatavuus: Open access -julkaisukanavassa ilmestynyt julkaisu

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/74329


Tiivistelmä

The frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of the periodic sound features in the ascending auditory system. Seminal studies suggested the FFR as a correlate of subcortical sound encoding, yet recent studies aiming to locate its sources challenged this assumption, demonstrating that FFR receives some contribution from the auditory cortex. Based on frequency-specific phase-locking capabilities along the auditory hierarchy, we hypothesized that FFRs to higher frequencies would receive less cortical contribution than those to lower frequencies, hence supporting a major subcortical involvement for these high frequency sounds. Here, we used a magnetoencephalographic (MEG) approach to trace the neural sources of the FFR elicited in healthy adults (N=19) to low (89 Hz) and high (333 Hz) frequency sounds. FFRs elicited to the high and low frequency sounds were clearly observable on MEG and comparable to those obtained in simultaneous electroencephalographic recordings. Distributed source modeling analyses revealed midbrain, thalamic, and cortical contributions to FFR, arranged in frequency-specific configurations. Our results showed that the main contribution to the high-frequency sound FFR originated in the inferior colliculus and the medial geniculate body of the thalamus, with no significant cortical contribution. In contrast, the low-frequency sound FFR had a major contribution located in the auditory cortices, and also received contributions originating in the midbrain and thalamic structures. These findings support the multiple generator hypothesis of the FFR and are relevant for our understanding of the neural encoding of sounds along the auditory hierarchy, suggesting a hierarchical organization of periodicity encoding.


YSO-asiasanat: kuulo; taajuus; ärsykkeet; MEG; kognitiivinen neurotiede; havaintopsykologia

Vapaat asiasanat: frequency following responses; magnetoencephalography; neural sources; auditory plasticity; speech sound encoding; fundamental frequency


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JYU-yksiköt:


OKM-raportointi: Kyllä

Alustava JUFO-taso: 2


Viimeisin päivitys 2021-30-04 klo 15:59