A1 Journal article (refereed)
Neural generators of the frequency-following response elicited to stimuli of low and high frequency : a magnetoencephalographic (MEG) study (2021)


Gorina-Careta, N., Kurkela, J. L., Hämäläinen, J., Astikainen, P., & Escera, C. (2021). Neural generators of the frequency-following response elicited to stimuli of low and high frequency : a magnetoencephalographic (MEG) study. NeuroImage, 231, Article 117866. https://doi.org/10.1016/j.neuroimage.2021.117866


JYU authors or editors


Publication details

All authors or editorsGorina-Careta, Natàlia; Kurkela, Jari L.O.; Hämäläinen, Jarmo; Astikainen, Piia; Escera, Carles

Journal or seriesNeuroImage

ISSN1053-8119

eISSN1095-9572

Publication year2021

Volume231

Article number117866

PublisherElsevier

Publication countryNetherlands

Publication languageEnglish

DOIhttps://doi.org/10.1016/j.neuroimage.2021.117866

Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/74329


Abstract

The frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of the periodic sound features in the ascending auditory system. Seminal studies suggested the FFR as a correlate of subcortical sound encoding, yet recent studies aiming to locate its sources challenged this assumption, demonstrating that FFR receives some contribution from the auditory cortex. Based on frequency-specific phase-locking capabilities along the auditory hierarchy, we hypothesized that FFRs to higher frequencies would receive less cortical contribution than those to lower frequencies, hence supporting a major subcortical involvement for these high frequency sounds. Here, we used a magnetoencephalographic (MEG) approach to trace the neural sources of the FFR elicited in healthy adults (N=19) to low (89 Hz) and high (333 Hz) frequency sounds. FFRs elicited to the high and low frequency sounds were clearly observable on MEG and comparable to those obtained in simultaneous electroencephalographic recordings. Distributed source modeling analyses revealed midbrain, thalamic, and cortical contributions to FFR, arranged in frequency-specific configurations. Our results showed that the main contribution to the high-frequency sound FFR originated in the inferior colliculus and the medial geniculate body of the thalamus, with no significant cortical contribution. In contrast, the low-frequency sound FFR had a major contribution located in the auditory cortices, and also received contributions originating in the midbrain and thalamic structures. These findings support the multiple generator hypothesis of the FFR and are relevant for our understanding of the neural encoding of sounds along the auditory hierarchy, suggesting a hierarchical organization of periodicity encoding.


Keywordssense of hearingfrequencystimuli (role related to effect)MEGcognitive neuroscienceperceptual psychology

Free keywordsfrequency following responses; magnetoencephalography; neural sources; auditory plasticity; speech sound encoding; fundamental frequency


Contributing organizations


Ministry reportingYes

Reporting Year2021

JUFO rating2


Last updated on 2024-03-04 at 20:06