A1 Journal article (refereed)
Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children (2022)

Haapala, E. A., Väistö, J., Ihalainen, J. K., Tomaselli González, C., Leppänen, M. H., Veijalainen, A., Sallinen, T., Eloranta, A.-M., Ekelund, U., Schwab, U., Brage, S., Atalay, M., & Lakka, T. A. (2022). Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children. European Journal of Sport Science, 22(6), 906-915. https://doi.org/10.1080/17461391.2021.1892830

JYU authors or editors

Publication details

All authors or editors: Haapala, Eero A.; Väistö, Juuso; Ihalainen, Johanna K.; Tomaselli González, Claudia; Leppänen, Marja H.; Veijalainen, Aapo; Sallinen, Taisa; Eloranta, Aino-Maija; Ekelund, Ulf; Schwab, Ursula; et al.

Journal or series: European Journal of Sport Science

ISSN: 1746-1391

eISSN: 1536-7290

Publication year: 2022

Publication date: 18/02/2021

Volume: 22

Issue number: 6

Pages range: 906-915

Publisher: Taylor & Francis

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1080/17461391.2021.1892830

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/74362

Abstract

We investigated the associations of physical activity (PA), sedentary time (ST), and diet quality with biomarkers of inflammation in 390 children (192 girls, 198 boys) aged 6-8 years. PA energy expenditure (PAEE), light PA, moderate PA (MPA), vigorous PA (VPA), moderate-to-vigorous PA (MVPA), and ST were assessed by combined movement and heart rate sensor. Finnish Children Healthy Eating Index was calculated using data from 4 d food records. Body fat percentage (BF%) was measured by dual-energy X-ray absorptiometry. High-sensitivity C-reactive protein (Hs-CRP), leptin, interleukin-6 (IL-6), adiponectin, tumour necrosis factor-α, and glycoprotein acetyls were measured from fasting blood samples. PAEE, MPA, VPA, and MVPA were inversely associated with hs-CRP (β=-191 to -139, 95% CI=-0.294 to -0.024), leptin (β=-0.409 to -0.301, 95% CI=-0.499 to -0.107), IL-6 (β=-0.136 to -0.104, 95% CI=-0.240 to -0.001) and PAEE, MPA, and MVPA were inversely associated with glycoprotein acetyls (β=-0.117 to -0.103, 95% CI=-0.213 to -0.001). ST was directly associated with hs-CRP (β=0.170, 95% CI=0.070 to 0.269), leptin (β=0.355, 95% CI=0.265 to 0.445), and IL-6 (β=0.105, 95% CI=0.005 to 0.205). VPA was inversely associated with hs-CRP, leptin, and IL-6 in children with higher BF% (β=-0.344 to -0.181, 95% CI=-0.477 to -0.033) but not among children with lower BF% (β=-0.007 to 0.033, 95% CI=-0.183 to 0.184). In conclusion, PA was inversely and ST directly associated with circulating levels of biomarkers of inflammation among children. Furthermore, we observed that PA was inversely associated with these biomarkers for inflammation in children with a higher BF%.

Keywords: children (age groups); inflammation; biomarkers; physical activity; exercise (people); nutrition; diets; body composition; obesity

Free keywords: inflammation; biomarkers; youth; exercise; nutrition; obesity

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2022

JUFO rating: 1