A2 Katsausartikkeli tieteellisessä aikausilehdessä
Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments (2021)

Hulmi, J. J., Nissinen, T. A., Penna, F., & Bonetto, A. (2021). Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments. Cells, 10(3), Article 516. https://doi.org/10.3390/cells10030516

JYU-tekijät tai -toimittajat

Hulmi, Juha
Nissinen, Tuuli

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Hulmi, Juha J.; Nissinen, Tuuli A.; Penna, Fabio; Bonetto, Andrea

Lehti tai sarja: Cells

eISSN: 2073-4409

Julkaisuvuosi: 2021

Volyymi: 10

Lehden numero: 3

Artikkelinumero: 516

Kustantaja: MDPI

Julkaisumaa: Sveitsi

Julkaisun kieli: englanti

DOI: https://doi.org/10.3390/cells10030516

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/74634

Tiivistelmä

Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting quality of life and overall survival in cancer patients. Pre-clinical studies have shown that blocking activin receptor type 2 (ACVR2) or its ligands and their downstream signaling can preserve muscle mass in rodents bearing experimental cancers, as well as in chemotherapy-treated animals. In tumor-bearing mice, the prevention of skeletal and respiratory muscle wasting was also associated with improved survival. However, the definitive proof that improved survival directly results from muscle preservation following blockade of ACVR2 signaling is still lacking, especially considering that concurrent beneficial effects in organs other than skeletal muscle have also been described in the presence of cancer or following chemotherapy treatments paired with counteraction of ACVR2 signaling. Hence, here, we aim to provide an up-to-date literature review on the multifaceted anti-cachectic effects of ACVR2 blockade in preclinical models of cancer, as well as in combination with anticancer treatments.

YSO-asiasanat: lihassurkastumasairaudet; syöpähoidot; henkiinjääminen; soluviestintä; proteiinit

Vapaat asiasanat: cancer cachexia; tumor; chemotherapy; myostatin; activins; muscle wasting; survival; mortality; multi-organ

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