A1 Journal article (refereed)
2,3-Dihydro-1,2,6-thiadiazine 1-Oxides by Biginelli-Type Reactions with Sulfonimidamides under Mechanochemical Conditions (2021)
Krauskopf, F., Truong, K.-N., Rissanen, K., & Bolm, C. (2021). 2,3-Dihydro-1,2,6-thiadiazine 1-Oxides by Biginelli-Type Reactions with Sulfonimidamides under Mechanochemical Conditions. Organic Letters, 23(7), 2699-2703. https://doi.org/10.1021/acs.orglett.1c00596
JYU authors or editors
Publication details
All authors or editors: Krauskopf,Felix; Truong, Khai-Nghi; Rissanen, Kari; Bolm, Carsten
Journal or series: Organic Letters
ISSN: 1523-7060
eISSN: 1523-7052
Publication year: 2021
Publication date: 19/03/2021
Volume: 23
Issue number: 7
Pages range: 2699-2703
Publisher: American Chemical Society (ACS)
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1021/acs.orglett.1c00596
Publication open access: Not open
Publication channel open access:
Abstract
Biginelli-type multicomponent reactions (MCRs) with NH-free sulfonimidamides provide 2,3-dihydro-1,2,6-thiadiazine 1-oxides in high yields. The couplings are performed in a planetary ball mill under solvent-free mechanochemical conditions. Acetic acid or ytterbium triflate are used as catalysts. A representative product was characterized by X-ray single crystal structure analysis revealing molecular details of the highly functionalized three-dimensional heterocycle. Further product modifications lead to additional structural scaffolds.
Free keywords: multicomponent reactions
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 2