A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains (2021)

Koskinen, K., Penttinen, R., Örmälä-Odegrip, A.-M., Giske, C. G., Ketola, T., & Jalasvuori, M. (2021). Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains. Frontiers in Cellular and Infection Microbiology, 11, Article 599924. https://doi.org/10.3389/fcimb.2021.599924

JYU-tekijät tai -toimittajat

Kiviaho, Katariina
Ketola, Tarmo
Jalasvuori, Matti

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Koskinen, Katariina; Penttinen, Reetta; Örmälä-Odegrip, Anni-Maria; Giske, Christian G.; Ketola, Tarmo; Jalasvuori, Matti

Lehti tai sarja: Frontiers in Cellular and Infection Microbiology

eISSN: 2235-2988

Julkaisuvuosi: 2021

Volyymi: 11

Artikkelinumero: 599924

Kustantaja: Frontiers Media

Julkaisumaa: Sveitsi

Julkaisun kieli: englanti

DOI: https://doi.org/10.3389/fcimb.2021.599924

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/74736

Julkaisu on rinnakkaistallennettu: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940544/

Tiivistelmä

Over the past few decades, extensively drug resistant (XDR) resistant Klebsiella pneumoniae has become a notable burden to healthcare all over the world. Especially carbapenemase-producing strains are problematic due to their capability to withstand even last resort antibiotics. Some sequence types (STs) of K. pneumoniae are significantly more prevalent in hospital settings in comparison to other equally resistant strains. This provokes the question whether or not there are phenotypic characteristics that may render certain K. pneumoniae more suitable for epidemic dispersal between patients, hospitals, and different environments. In this study, we selected seven epidemic and non-epidemic carbapenem resistant K. pneumoniae isolates for extensive systematic characterization for phenotypic and genotypic qualities in order to identify potential factors that precede or emerge from epidemic successfulness. Studied characteristics include growth rates and densities in different conditions (media, temperature, pH, resource levels), tolerance to alcohol and drought, inhibition between strains, ability to compensate pH, as well as various genomic features. Overall, there are clear differences between isolates, yet, only drought tolerance was found to notably associate with non-epidemic K. pneumoniae strains. We further report a preliminary study on the potential to control K. pneumoniae ST11 with an antimicrobial component produced by a non-epidemic K. pneumoniae. This component initially restricts bacterial growth, but stable resistance develops rapidly in vitro.

YSO-asiasanat: bakteerit; Klebsiella-bakteerit; virulenssi; antibioottiresistenssi; epidemiat

Vapaat asiasanat: XDR Klebsiella pneumoniae; extended-spectrum beta-lactamase; epidemic; antibiotic resistance; virulence

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