A1 Journal article (refereed)
2-Sulfoximidoyl Acetic Acids from Multicomponent Petasis Reactions and Their Use as Building Blocks in Syntheses of Sulfoximine Benzodiazepine Analogues (2021)
Hommelsheim, R., Núñez Ponce, H. M., Truong, K.-N., Rissanen, K., & Bolm, C. (2021). 2-Sulfoximidoyl Acetic Acids from Multicomponent Petasis Reactions and Their Use as Building Blocks in Syntheses of Sulfoximine Benzodiazepine Analogues. Organic Letters, 23(9), 3415-3420. https://doi.org/10.1021/acs.orglett.1c00874
JYU authors or editors
Publication details
All authors or editors: Hommelsheim, René; Núñez Ponce, Heliana Michaela; Truong, Khai-Nghi; Rissanen, Kari; Bolm, Carsten
Journal or series: Organic Letters
ISSN: 1523-7060
eISSN: 1523-7052
Publication year: 2021
Volume: 23
Issue number: 9
Pages range: 3415-3420
Publisher: American Chemical Society
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1021/acs.orglett.1c00874
Publication open access: Not open
Publication channel open access:
Abstract
Upon application of a multicomponent Petasis reaction, a broad range of NH-sulfoximines and boronic acids react with glyoxalic acid to afford the corresponding 2-substituted acetic acids with N-bound sulfoximidoyl groups. The protocol features excellent yields under ambient, metal-free conditions and short reaction times. Furthermore, the applicability of 2-sulfoximidoyl acetic acids as building blocks for synthesizing sulfoximine-based benzodiazepine analogues was demonstrated.
Keywords: chemistry; chemical reactions
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 2