A1 Journal article (refereed)
2-Sulfoximidoyl Acetic Acids from Multicomponent Petasis Reactions and Their Use as Building Blocks in Syntheses of Sulfoximine Benzodiazepine Analogues (2021)


Hommelsheim, R., Núñez Ponce, H. M., Truong, K.-N., Rissanen, K., & Bolm, C. (2021). 2-Sulfoximidoyl Acetic Acids from Multicomponent Petasis Reactions and Their Use as Building Blocks in Syntheses of Sulfoximine Benzodiazepine Analogues. Organic Letters, 23(9), 3415-3420. https://doi.org/10.1021/acs.orglett.1c00874


JYU authors or editors


Publication details

All authors or editorsHommelsheim, René; Núñez Ponce, Heliana Michaela; Truong, Khai-Nghi; Rissanen, Kari; Bolm, Carsten

Journal or seriesOrganic Letters

ISSN1523-7060

eISSN1523-7052

Publication year2021

Volume23

Issue number9

Pages range3415-3420

PublisherAmerican Chemical Society

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1021/acs.orglett.1c00874

Publication open accessNot open

Publication channel open access


Abstract

Upon application of a multicomponent Petasis reaction, a broad range of NH-sulfoximines and boronic acids react with glyoxalic acid to afford the corresponding 2-substituted acetic acids with N-bound sulfoximidoyl groups. The protocol features excellent yields under ambient, metal-free conditions and short reaction times. Furthermore, the applicability of 2-sulfoximidoyl acetic acids as building blocks for synthesizing sulfoximine-based benzodiazepine analogues was demonstrated.


Keywordschemistrychemical reactions


Contributing organizations


Ministry reportingYes

Reporting Year2021

JUFO rating2


Last updated on 2024-26-03 at 09:19