A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms : Findings from Helsinki birth cohort study (2021)
Eriksson, M. D., Eriksson, J. G., Kautiainen, H., Salonen, M. K., Mikkola, T. M., Kajantie, E., Wasenius, N., von Bonsdorff, M., & Laine, M. K. (2021). Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms : Findings from Helsinki birth cohort study. Journal of Psychosomatic Research, 145, Article 110488. https://doi.org/10.1016/j.jpsychores.2021.110488
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Eriksson, Mia D.; Eriksson, Johan G.; Kautiainen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Kajantie, Eero; Wasenius, Niko; von Bonsdorff, Mikaela; Laine, Merja K.
Lehti tai sarja: Journal of Psychosomatic Research
ISSN: 0022-3999
eISSN: 1879-1360
Julkaisuvuosi: 2021
Volyymi: 145
Artikkelinumero: 110488
Kustantaja: Elsevier
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1016/j.jpsychores.2021.110488
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/75347
Tiivistelmä
Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms.
Methods
From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex.
Results
Of women, 27% scored ≥10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model.
Conclusions
The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study.
YSO-asiasanat: masennus; tulehdus; biomarkkerit; aineenvaihduntatuotteet; komorbiditeetti; ikääntyneet; kohorttitutkimus
Vapaat asiasanat: advanced glycation end products; biomarkers; cohort studies; comorbidity; depression; depressive disorder; inflammation
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2021
JUFO-taso: 1
