A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome (2021)

Sievänen, T., Törmäkangas, T., Laakkonen, E. K., Mecklin, J.-P., Pylvänäinen, K., Seppälä, T. T., Peltomäki, P., Sipilä, S., & Sillanpää, E. (2021). Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome. Cancers, 13(8), Article 1849. https://doi.org/10.3390/cancers13081849

JYU-tekijät tai -toimittajat

Sievänen, Tero
Törmäkangas, Timo
Laakkonen, Eija
Mecklin, Jukka-Pekka
Sipilä, Sarianna
Sillanpää, Elina

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Sievänen, Tero; Törmäkangas, Timo; Laakkonen, Eija K.; Mecklin, Jukka-Pekka; Pylvänäinen, Kirsi; Seppälä, Toni T.; Peltomäki, Päivi; Sipilä, Sarianna; Sillanpää, Elina

Lehti tai sarja: Cancers

eISSN: 2072-6694

Julkaisuvuosi: 2021

Ilmestymispäivä: 13.04.2021

Volyymi: 13

Lehden numero: 8

Artikkelinumero: 1849

Kustantaja: MDPI AG

Julkaisumaa: Sveitsi

Julkaisun kieli: englanti

DOI: https://doi.org/10.3390/cancers13081849

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/75079

Tiivistelmä

Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS.

YSO-asiasanat: perinnölliset taudit; Lynchin oireyhtymä; suolistosyövät; riskitekijät; elintavat; ylipaino; fyysinen aktiivisuus; epidemiologia