A1 Journal article (refereed)
Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome (2021)

Sievänen, T., Törmäkangas, T., Laakkonen, E. K., Mecklin, J.-P., Pylvänäinen, K., Seppälä, T. T., Peltomäki, P., Sipilä, S., & Sillanpää, E. (2021). Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome. Cancers, 13(8), Article 1849. https://doi.org/10.3390/cancers13081849

JYU authors or editors

Sievänen, Tero
Törmäkangas, Timo
Laakkonen, Eija
Mecklin, Jukka-Pekka
Sipilä, Sarianna
Sillanpää, Elina

Publication details

All authors or editors: Sievänen, Tero; Törmäkangas, Timo; Laakkonen, Eija K.; Mecklin, Jukka-Pekka; Pylvänäinen, Kirsi; Seppälä, Toni T.; Peltomäki, Päivi; Sipilä, Sarianna; Sillanpää, Elina

Journal or series: Cancers

eISSN: 2072-6694

Publication year: 2021

Publication date: 13/04/2021

Volume: 13

Issue number: 8

Article number: 1849

Publisher: MDPI AG

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3390/cancers13081849

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/75079

Abstract

Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS.

Keywords: hereditary diseases; Lynch syndrome; bowel cancer; risk factors; lifestyle habits; overweight; physical activity; epidemiology