A1 Journal article (refereed)
Musculoskeletal Responses to Exercise plus Nutrition in Men with Prostate Cancer on Androgen Deprivation : A 12-month RCT (2021)

Via, J. D., Owen, P. J., Daly, R. M., Mundell, N. L., Livingston, P. M., Rantalainen, T., Foulkes, S. J., Millar, J. L., Murphy, D. G., & Fraser, S. F. (2021). Musculoskeletal Responses to Exercise plus Nutrition in Men with Prostate Cancer on Androgen Deprivation : A 12-month RCT. Medicine and Science in Sports and Exercise, 53(10), 2054-2065. https://doi.org/10.1249/mss.0000000000002682

JYU authors or editors

Publication details

All authors or editors: Via, Jack Dalla; Owen, Patrick J.; Daly, Robin M.; Mundell, Niamh L.; Livingston, Patricia M.; Rantalainen, Timo; Foulkes, Stephen J.; Millar, Jeremy L.; Murphy, Declan G.; Fraser, Steve F.

Journal or series: Medicine and Science in Sports and Exercise

ISSN: 0195-9131

eISSN: 1530-0315

Publication year: 2021

Volume: 53

Issue number: 10

Pages range: 2054-2065

Publisher: Lippincott Williams & Wilkins

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1249/mss.0000000000002682

Publication open access: Not open

Publication channel open access: Channel is not openly available

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/75142


Androgen deprivation therapy (ADT) for prostate cancer (PCa) has multiple adverse effects on musculoskeletal health. This 12-month randomised controlled trial aimed to assess the effects of multi-component exercise training combined with whey protein, calcium and vitamin D supplementation on bone mineral density (BMD), structure and strength, body composition, muscle strength and physical function in ADT-treated men.

Seventy ADT-treated men were randomised to exercise plus supplementation (Ex+Suppl; n=34) or usual care (Control; n=36). Ex+Suppl involved thrice weekly progressive resistance training plus weight-bearing impact exercise with daily multi-nutrient supplementation. Primary outcomes were DXA hip and spine areal BMD. Secondary outcomes included: tibia and radius pQCT volumetric BMD, bone structure and strength; DXA body composition; pQCT muscle and fat cross-sectional area and muscle density; muscle strength and physical function.

Sixty men (86%) completed the study. Mean exercise and supplement adherence were 56% and 77%, respectively. There were no effects of the intervention on bone or body composition outcomes. Ex+Suppl improved leg muscle strength (net difference [95% CI] 14.5% [-0.2, 29.2], P=0.007) and dynamic mobility (four-square-step test time, -9.3% [-17.3, -1.3], P=0.014) relative to controls. Per-protocol analysis of adherent participants (≥66% exercise, ≥80% supplement) showed Ex+Suppl preserved femoral neck aBMD (1.9% [0.1, 3.8], P=0.026) and improved total body lean mass (1.0 kg [-0.23, 2.22], P=0.044) relative to controls.

Exercise training combined with multi-nutrient supplementation had limited effect on ameliorating the adverse musculoskeletal consequences of ADT, likely related to the modest intervention adherence.

Keywords: exercise (people); nutrition; cancerous diseases; prostate cancer; cancer treatments; skeletal system; muscles

Free keywords: exercise; nutrition; cancer; bone; muscle; androgen deprivation therapy

Contributing organizations

Ministry reporting: Yes

Preliminary JUFO rating: 3

Last updated on 2021-17-09 at 15:58